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Parente, JN; Talhari, C; Schettini, AP; Massone, C.
T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states.
An Bras Dermatol. 2015; 90(1):41-47 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Massone Cesare
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Abstract:
Leprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies. This study aimed to verify the frequency and distribution of regulatory T cells in different clinical forms and reactional states of leprosy. We performed an immunohistochemical study on 96 leprosy cases [Indeterminate (I): 9 patients; tuberculoid tuberculoid: 13 patients; borderline tuberculoid: 26 patients; borderline borderline: 3 patients; borderline lepromatous: 8 patients; lepromatous lepromatous: 27 patients; reversal reaction: 8 patients; and erythema nodosum leprosum: 2 patients]. FoxP3-positive cells were present in 100% of the cases with an average density of 2.82% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was a statistically significant increment of FoxP3 expression in patients with leprosy reversal reactions when compared with patients presenting with type I leprosy (P= 0.0228); borderline tuberculoid leprosy (P = 0.0351) and lepromatous leprosy (P = 0.0344). These findings suggest that Tregs play a relevant role in the etiopathogenesis of leprosy, mainly in type I leprosy reaction.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Biopsy -
Child -
Child, Preschool -
Cytokines - analysis
Female -
Forkhead Transcription Factors - analysis
Granuloma - pathology
Humans -
Immunohistochemistry -
Interleukin-2 Receptor alpha Subunit - analysis
Leprosy - pathology
Male -
Middle Aged -
Retrospective Studies -
Skin - pathology
T-Lymphocytes, Regulatory - pathology
Young Adult -

Find related publications in this database (Keywords)
Leprosy
T-Lymphocytes
T-Lymphocytes, regulatory
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