Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Moscarella, E; Kyrgidis, A; Sperduti, I; Abramavicus, A; Argenziano, G; Cota, C; Eibenschutz, L; De Simone, P; Longo, C; Hofmann-Wellenhof, R; Zalaudek, I.
Age-related prevalence and morphological appearance of facial skin tumours: a prospective, cross-sectional, observational, multicentre study with special emphasis on melanocytic tumours.
J Eur Acad Dermatol Venereol. 2015; 29(7):1331-1338
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Hofmann-Wellenhof Rainer
Zalaudek Iris

Dimensions Citations:

Plum Analytics:
The clinical and histopathological diagnosis of skin tumours arising on the face may be challenging. An improved knowledge about the age-related patterns of facial skin tumours may aid the correct diagnosis and management. We conducted a prospective, cross-sectional morphological study to investigate the age-related frequency and morphological variability in facial skin tumours in a cohort of consecutive subjects attending two skin lesion clinics in Italy between June and September 2011. A total of 454 consecutive subjects (249 women; 55.5%) presenting with a total of 1866 facial tumours were enrolled in the study. Of the entire cohort, 54 (11.9%) subjects had no facial lesion. Total body naevus count correlated significantly with the mean number of facial lesions (ρ = 0.289, P < 0.001). The majority of flat lesions were pigmented (1056; 75.70%), compared to palpable (233; 17.40%) and raised lesions (93; 6.90%), the association being statistically significant (Pearson's chi square, P < 0.001. Considering melanocytic tumours only, the frequency of flat lesions significantly decreased with increasing age, while the number of palpable and raised lesions increased with increasing age (chi-square, P < 0.001). This trend was mainly due to naevi, whereby pigmented melanocytic naevi decreased with increasing age. Conversely, the percentage of non- pigmented naevi increased with increasing age (chi-square, P < 0.001). The study was conducted in skin lesion clinics in Italy, thus any general conclusions with respect to common traits or features based on the phenotypic and genetic diversity within the European population cannot be stated. Our study suggests that a high number of facial naevi could predict a high total naevus count. Moreover, naevi present a different morphological appearance during lifetime being initially flat, small and pigmented and becoming later raised, large and hypopigmented. Instead, lentigo maligna is an intraepidermal proliferation that typically presents as flat, large pigmented macule. A given histopathological diagnosis of a junctional naevus of a flat, facial pigmented macule of an elderly should be critically reviewed and treated with caution. © 2014 European Academy of Dermatology and Venereology.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Biopsy -
Child -
Child, Preschool -
Cross-Sectional Studies -
Facial Neoplasms - epidemiology
Facial Neoplasms - pathology
Female -
Humans -
Infant -
Infant, Newborn -
Infant, Newborn - epidemiology
Male -
Middle Aged -
Nevus, Pigmented - epidemiology
Nevus, Pigmented - pathology
Prevalence -
Prospective Studies -
Skin - pathology
Skin Neoplasms - epidemiology
Skin Neoplasms - pathology
Young Adult -

© Meduni Graz Impressum