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SHR Neuro Krebs Kardio Lipid

Machan, S; El Shabrawi-Caelen, L; Nikolay, E; Kerl, H; Requena, L; Cerroni, L.
Follicular malignant melanoma: primary follicular or folliculotropic?
Am J Dermatopathol. 2015; 37(1):15-19 (- Case Report)
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Cerroni Lorenzo
El-Shabrawi-Caelen Laila
Kerl Helmut
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Abstract:
Follicular malignant melanoma (FMM) is a rare variant of melanoma arising on sun-damaged skin of elderly patients. It is characterized histopathologically by a prominent involvement of 1 or 2 adjacent hair follicles. The authors report 3 new cases of FMM (M:F = 2:1; age range, 23-67 years; median age, 50 years) located on the scalp, cheek, and upper back. Complete effacement of the hair follicle, replaced by neoplastic melanocytes, was observed in 1 case. The interfollicular epidermis and adventitial dermis were involved in all 3 cases. Our series shows that FMM is not restricted to elderly patients but may arise also in young individuals without association with chronic sun damage. FMM should be distinguished from folliculotropic metastases of melanoma and from atypical melanocytic nevi. Although the histopathological features and the term FMM may suggest a derivation from melanocytes of the hair follicle, the exact origin of neoplastic cells is yet unclear, and at least some of these cases may represent folliculotropic examples of primary epidermal malignant melanoma.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Biomarkers, Tumor - analysis
Biopsy -
Diagnosis, Differential -
Female -
Hair Follicle - chemistry
Hair Follicle - pathology
Head and Neck Neoplasms - chemistry
Head and Neck Neoplasms - classification
Head and Neck Neoplasms - pathology
Humans -
Immunohistochemistry -
Male -
Melanocytes - chemistry
Melanocytes - pathology
Melanoma - chemistry
Melanoma - classification
Melanoma - pathology
Middle Aged -
Predictive Value of Tests -
Scalp - chemistry
Scalp - pathology
Skin Neoplasms - chemistry
Skin Neoplasms - classification
Skin Neoplasms - pathology
Young Adult -

Find related publications in this database (Keywords)
follicular malignant melanoma
folliculotropic metastatic melanoma
malignant melanoma
hair follicles
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