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Gruber-Wackernagel, A; Byrne, SN; Wolf, P.
Polymorphous light eruption: clinic aspects and pathogenesis.
Dermatol Clin. 2014; 32(3):315-334
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Gruber-Wackernagel Alexandra
Wolf Peter
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Abstract:
Polymorphous light eruption is an immunologically mediated photodermatosis with high prevalence, particularly among young women in temperate climates, characterized by pruritic skin lesions of variable morphology, occurring in spring or early summer on sun-exposed body sites. A resistance to ultraviolet radiation (UVR)-induced immunosuppression and a subsequent delayed-type hypersensitivity response to a photoantigen have been suggested as key factors in the disease. Molecular and immunologic disturbances associated with disease pathogenesis include a failure of skin infiltration by neutrophils and other regulatory immune cells on UVR exposure linked to a disturbed cytokine microenvironment. Standard management is based on prevention. Copyright © 2014 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Disease Management -
Humans -
Immunosuppression - adverse effects
Photosensitivity Disorders - diagnosis
Photosensitivity Disorders - epidemiology
Photosensitivity Disorders - etiology
Prevalence -
Skin - pathology
Skin - radiation effects
Ultraviolet Rays - adverse effects

Find related publications in this database (Keywords)
Polymorphous light eruption
Polymorphic
Photoantigen
Immune suppression
Cytokines
Chemotaxis
Photoprotection
Skin cancer
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