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Aberer, E; Savic, S; Bretterklieber, A; Reiter, H; Berghold, A; Aberer, W.
Disease spectrum in patients with elevated serum tryptase levels.
Australas J Dermatol. 2015; 56(1):7-13
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Autor/innen der Med Uni Graz:
Aberer Elisabeth
Aberer Werner
Berghold Andrea
Bretterklieber Agnes
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Abstract:
Elevated serum tryptase levels can be a sign of mastocytosis, which is a rare disease associated with systemic and/or skin manifestations. To investigate patients with elevated tryptase levels in regard to their underlying diseases, and to determine whether increased tryptase can be used as a diagnostic marker for underlying mastocytosis. In a retrospective study the data of 96 patients with serum tryptase levels higher than 15 μg/L were systematically analysed. In 48 patients control investigations for baseline tryptase were performed. Fifty-three of the 96 patients had tryptase levels ≥20 μg/L. A mere 16% of the 96 patients suffered from mastocytosis and had the highest tryptase levels (P < 0.001). The remaining patients had anaphylaxis (36%), urticaria and angioedema (26%), local reactions to insect bites (4%), drug reactions (3%), or miscellaneous diagnoses (15%). Only 16 of these had acute symptoms at tryptase investigation. In all, 48 patients had a follow up; in 7/48 patients with acute symptoms normal tryptase levels were seen at control investigations, but 41/48 (85%) patients showed continuously elevated tryptase levels >15 μg/L and in 30 patients (62%) even values >20 μg/L; 11 of these patients had anaphylaxis, five urticaria, five other diagnoses and nine patients mastocytosis. More than 50% of patients with non-mastocytosis such as urticaria and angioedema, drug or anaphylactic reactions repeatedly had tryptase levels higher than 20 μg/L. Since baseline tryptase >20 μg/L is a minor criterion for mastocytosis, these patients should be inspected for skin lesions of mastocytosis and receive a diagnostic body work-up for systemic mastocytosis including a bone marrow biopsy. © 2014 The Australasian College of Dermatologists.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Anaphylaxis - blood
Angioedema - blood
Biomarkers - blood
Female -
Humans -
Insect Bites and Stings - blood
Male -
Mastocytosis - blood
Mastocytosis - diagnosis
Middle Aged -
Retrospective Studies -
Tryptases - blood
Urticaria - blood
Young Adult -

Find related publications in this database (Keywords)
anaphylaxis
mastocytosis
tryptase
urticaria
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