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SHR Neuro Krebs Kardio Lipid

Sturm, GJ; Kranzelbinder, B; Schuster, C; Sturm, EM; Bokanovic, D; Vollmann, J; Crailsheim, K; Hemmer, W; Aberer, W.
Sensitization to Hymenoptera venoms is common, but systemic sting reactions are rare.
J Allergy Clin Immunol. 2014; 133(6):1635-1643
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Autor/innen der Med Uni Graz:
Aberer Werner
Bokanovic Danijela
Kranzelbinder Bettina
Schuster Christian
Sturm Eva
Sturm Gunter
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Abstract:
Sensitization to Hymenoptera venom without systemic sting reactions (SSRs) is commonly observed in the general population. Clinical relevance for a future sting has not yet been investigated. We aimed to evaluate the effect of these debatable sensitizations with deliberate sting challenges and to monitor serologic changes for up to 2 years. One hundred thirty-one challenges with bees and wasps were performed in 94 subjects with a hitherto irrelevant sensitization. The clinical outcome was recorded, and results of specific IgE (sIgE) determinations, skin tests, and basophil activation tests were correlated to the sting reaction. sIgE levels were monitored in reactors and nonreactors after 3 hours, 1 week, 4 weeks, and 1 year. Only 5 (5.3%) patients had SSRs, but 41 (43.6%) had large local reactions (LLRs) after the sting. Compared with the general population, there was a 9.5-fold higher risk for LLRs but not for SSRs. Three hours after the sting, sIgE levels slightly decreased, but none of the 94 subjects' results turned negative. After 1 week, sIgE levels already increased, increasing up to 3.5-fold (range, 0.2- to 34.0-fold) baseline levels after 4 weeks. To assess the clinical relevance of this increase, we randomly selected 18 patients for a re-sting. Again, 50% had an LLR, but none had an SSR. Although sensitization to Hymenoptera venoms was common, the risk of SSRs in sensitized subjects was low in our study. The sIgE level increase after the sting was not an indicator for conversion into symptomatic sensitization. Currently available tests were not able to distinguish between asymptomatic sensitization, LLRs, and SSRs. Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Allergens - immunology
Animals -
Arthropod Venoms - adverse effects
Female -
Humans -
Hymenoptera - immunology
Hypersensitivity - diagnosis
Hypersensitivity - immunology
Immunoglobulin E - blood
Immunoglobulin E - immunology
Insect Bites and Stings - diagnosis
Insect Bites and Stings - immunology
Male -
Patient Outcome Assessment -
Skin Tests -
Time Factors -
Young Adult -

Find related publications in this database (Keywords)
Asymptomatic sensitization
basophil activation test
component-resolved diagnosis
IgE determination
intradermal test
large local reaction
sting challenge
systemic sting reaction
total IgE
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