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SHR Neuro Krebs Kardio Lipid

Ahlgrimm-Siess, V; Cao, T; Oliviero, M; Laimer, M; Hofmann-Wellenhof, R; Rabinovitz, HS; Scope, A; .
Seborrheic keratosis: Reflectance confocal microscopy features and correlation with dermoscopy.
J Am Acad Dermatol. 2013; 69(1):120-126
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Autor/innen der Med Uni Graz:
Ahlgrimm-Siess Verena
Hofmann-Wellenhof Rainer
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Abstract:
Background: Differentiation between seborrheic keratosis (SK) and skin cancers may be difficult. Reflectance confocal microscopy (RCM) enables noninvasive assessment of skin neoplasms at cellular-level resolution. Objective: We sought to describe RCM features of SK and to correlate these RCM findings with dermoscopic structures. Methods: Clinical, dermoscopic, and RCM images of 45 consecutive SK were obtained at a private and university dermatology clinic. Fourteen SK were biopsied because of equivocal clinical or dermoscopic features. Results: With RCM, all SK displayed a regular honeycomb pattern of the epidermis and densely packed, round to polymorphous, well-circumscribed dermal papillae at the dermoepidermal junction, features suggestive of a benign neoplasm. RCM features indicating the diagnosis of SK were also observed, including epidermal projections (43/45 SK; 96%) and keratin-filled invaginations (36/45 SK; 80%) at the lesion surface; corneal pseudocysts at epidermal layers (19/45 SK; 42%); and melanophages (21/45 SK; 47%) and dilated round and linear blood vessels (21/45 SK; 47%) in the papillary dermis. Of biopsied SK, 93% (13/14) displayed at least 3 characteristic RCM findings in the absence of RCM features suggestive of malignancy. Limitations: This was a limited study sample and retrospective study design. Conclusions: SK display a distinct set of RCM criteria despite their variable clinical and dermoscopic appearances.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Dermoscopy -
Epidermis - pathology
Female -
Humans -
Keratosis, Seborrheic - diagnosis
Lentigo - pathology
Male -
Microscopy, Confocal - methods
Middle Aged -
Retrospective Studies -
Skin Neoplasms - diagnosis

Find related publications in this database (Keywords)
dermoscopy
histopathology
in vivo reflectance confocal microscopy
seborrheic keratoses
solar lentigo
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