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Singh, TP; Schön, MP; Wallbrecht, K; Wolf, P.
8-Methoxypsoralen plus UVA treatment increases the proportion of CLA+ CD25+ CD4+ T cells in lymph nodes of K5.hTGFβ1 transgenic mice.
Exp Dermatol. 2012; 21(3):228-230 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Singh Tej Pratap
Wolf Peter
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Abstract:
8-Methoxypsoralen plus UVA (PUVA) photochemotherapy is an effective treatment for many skin diseases including psoriasis. However, its exact mechanism of therapeutic action is incompletely understood. Previously, in K5.hTGFβ1 transgenic psoriatic mice, we found that PUVA induces Foxp3+ CD25+ CD4+ regulatory T cells in both lymph node and spleen. Now, in the same model, we investigated whether cutaneous lymphocyte-associated antigen (CLA) mediates PUVA's effect on homing of CD25+ CD4+  T cells to the lymph nodes of K5.hTGFβ1 transgenic mice. We found that a low dose of topical PUVA maximally increased the proportion of CLA + CD25+ CD4 + T cells in the lymph nodes by up to 8-fold. We also observed an increased number of Foxp3+ CD25+  T cells in the skin of the mice after PUVA treatment. Together, these findings suggest that PUVA affects the homing of regulatory T cells.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Antigens, Differentiation, T-Lymphocyte - drug effects
Disease Models, Animal -
Interleukin-2 Receptor alpha Subunit - drug effects
Lymph Nodes - cytology
Methoxsalen - administration & dosage
Mice -
Mice, Transgenic -
PUVA Therapy -
Photosensitizing Agents - administration & dosage
Psoriasis - drug therapy
T-Lymphocytes - drug effects
T-Lymphocytes, Regulatory - drug effects

Find related publications in this database (Keywords)
cutaneous lymphocyte-associated antigen
psoralen
psoriasis
T-cell homing
UVA
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