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Becker, JC; Schrama, D.
Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.
J INVEST DERMATOL. 2012; 132(1): 15-17. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Becker Jürgen Christian
Schrama David
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Abstract:
The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-ã-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
CD4-Positive T-Lymphocytes - immunology
Immune Tolerance - immunology
Oxidoreductases - immunology
Vitiligo - immunology

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