Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Gantner, S; Wiesner, T; Cerroni, L; Lurkin, I; Zwarthoff, EC; Landthaler, M; Hafner, C.
Absence of BRAF and HRAS mutations in eruptive Spitz naevi
BRIT J DERMATOL. 2011; 164(4): 873-877. (- Case Report)
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Cerroni Lorenzo
Wiesner Thomas

Dimensions Citations:

Plum Analytics:
Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. To investigate the genetic changes underlying eruptive Spitz naevi. We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions  Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
DNA Mutational Analysis -
Genes, ras -
Humans -
Male -
Mutation -
Nevus, Epithelioid and Spindle Cell - genetics Nevus, Epithelioid and Spindle Cell - pathology
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins p21(ras) - genetics

© Meduni Graz Impressum