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Gruber-Wackernagel, A; Heinemann, A; Konya, V; Byrne, SN; Singh, TP; Hofer, A; Legat, F; Wolf, P.
Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption.
Exp Dermatol. 2011; 20(6):473-476
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Autor/innen der Med Uni Graz:
Gruber-Wackernagel Alexandra
Heinemann Akos
Hofer Angelika
Konya Viktoria
Legat Franz
Singh Tej Pratap
Wolf Peter
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Abstract:
A failure to induce immune suppression after UV exposure has been implicated in the pathogenesis of polymorphic light eruption (PLE). This immunological resistance has been linked to an impaired neutrophil infiltration into the skin following UV exposure. Therapeutic photohardening can restore this abnormal neutrophil infiltration in PLE skin and is thought to be responsible for the prophylactic efficacy. The aim of this study was to elucidate the pathogenic mechanism of the described neutrophil deficiency in PLE. Peripheral blood neutrophil responses to the chemoattractants leukotriene B4 (LTB(4)) and formyl-methionyl-leucyl-phenylalanin (fMLP) were investigated in vitro. Samples from 10 patients with PLE before and after 6 weeks of photohardening therapy were assessed. Flow cytometry was used to measure the changes associated with neutrophil activation. We found a significantly reduced neutrophil responsiveness to LTB(4) and fMLP in PLE patients, which was restored to normal levels after phototherapy. Indeed, PLE neutrophil responsiveness to these two chemoattractants after (but not before) phototherapy was similar to that of age- and sex-matched healthy control subjects. This indicates that an abnormal chemotactic potential to neutrophils is a crucial factor in the pathogenesis of PLE. Normalization following photohardening may therefore account for the therapeutic efficacy by restoring UV-induced neutrophil skin infiltration. Our results reveal a completely novel pathogenic mechanism involved in PLE and offer unique targets for therapy. © 2011 John Wiley & Sons A/S.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Chemotactic Factors - pharmacology
Chemotaxis, Leukocyte - drug effects
Female -
Humans -
In Vitro Techniques -
Leukotriene B4 - pharmacology
Light -
Male -
Middle Aged -
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
Neutrophil Activation - drug effects
Neutrophil Activation - radiation effects
Neutrophil Infiltration - drug effects
Neutrophil Infiltration - radiation effects
Neutrophils - drug effects
Neutrophils - physiology
Neutrophils - radiation effects
Photosensitivity Disorders - etiology
Photosensitivity Disorders - immunology
Photosensitivity Disorders - pathology
Photosensitivity Disorders - therapy
Phototherapy -
Ultraviolet Rays -

Find related publications in this database (Keywords)
chemoattractants
chemotactic deficiency
immunosuppression
neutrophils
photohardening
polymorphic light eruption
ultraviolet radiation
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