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SHR Neuro Krebs Kardio Lipid

Nawka, T; Sittel, C; Gugatschka, M; Arens, C; Lang-Roth, R; Wittekindt, C; Hagen, R; Müller, AH; Volk, GF; Guntinas-Lichius, O.
Permanent transoral surgery of bilateral vocal fold paralysis: a prospective multi-center trial.
Laryngoscope. 2015; 125(6):1401-1408
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Gugatschka Markus
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Abstract:
To describe postoperative adverse events (AEs) and outcomes after transoral surgery for bilateral vocal fold paralysis (BVFP). Prospective observational multicenter study. Thirty-six patients with BVFP underwent transoral surgery using standard surgical procedures to unilaterally widen the glottic area. Postoperative adverse events (AEs) including severe adverse events (SAEs) were registered continuously. Pre- and 6-month postoperative evaluations included the 6-Minute Walk Test, the 36-Item Short Form Health Survey (SF-36), the Glasgow Benefit Inventory, the 12-Item Voice Handicap Index (VHI-12), and a Fiberoptic Endoscopic Evaluation of Swallowing graded according to the Penetration-Aspiration-Scale. The patients underwent posterior cordotomy, partial arytenoidectomy, or permanent laterofixation as single procedures or in combination. Forty-seven percent of the patients had postoperative AEs. Dyspnea was the most frequent AE (45%). In 40% of AEs, the events were severe (SAEs), and 72.5% were related to the study intervention. Revision surgery leading to prolonged hospitalization or rehospitalization was necessary in nine cases (25%). Laterofixation was correlated to a decreased risk of AEs (P = 0.042). Six months after surgery, a significant improvement was seen in the SF-domains: Physical component score (P = 0.008), physical functioning (P = 0.001), physical role (P = 0.031), and vitality (P = 0.032). Concerning the voice handicap, only the VHI-12 physical subscore showed a decrease (P = 0.005). The total score and other VHI-12 subscores did not change significantly (all P > 0.05). BCVP patients profit from modern transoral surgery for unilateral glottic widening; quality of life is improved; and the voice is preserved. Nevertheless, postoperative complications are frequent. 2b. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Female -
Health Status Indicators -
Humans -
Male -
Middle Aged -
Otorhinolaryngologic Surgical Procedures - methods
Prospective Studies -
Quality of Life -
Treatment Outcome -
Vocal Cord Paralysis - surgery
Young Adult -

Find related publications in this database (Keywords)
Bilateral vocal fold paralysis
treatment outcome
prospective study
transoral approach
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