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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Richtig, E; Trapp, EM; Avian, A; Brezinsek, HP; Trapp, M; Egger, JW; Kapfhammer, HP; Rohrer, PM; Berghold, A; Curiel-Lewandrowski, C; Demel, U.
Psychological Stress and Immunological Modulations in Early-stage Melanoma Patients.
Acta Derm Venereol. 2015; 95(6):691-695 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Avian Alexander
Berghold Andrea
Brezinschek Hans-Peter
Demel Ulrike
Egger Josef Wilhelm
Kapfhammer Hans-Peter
Richtig Erika
Rohrer Peter Michael
Trapp Eva-Maria
Trapp Michael

Dimensions Citations:

Plum Analytics:
Mental stress may have a negative impact on the immune state of cancer patients, in whom immunologic surveillance is essential for survival. This study investigated the immunological response of 19 patients with early-stage melanoma and a matched control group undergoing the Determination Stress Test before surgery. Cytokine and chemokine levels and lymphocyte subpopulations were measured at baseline and post-stress test time-points. Following the stress test lower levels of interleukin (IL)-6 were observed in the melanoma group compared with healthy volunteers (p = 0.044). IL-10 increased significantly in the control group 30 min after the stress test (p = 0.002) in comparison with the melanoma group (p = 0.407). CCL5/Rantes decreased significantly in the melanoma group, whereas CD16/CD56+ natural killer cells increased in both groups, with a sharp decrease below baseline after stress in the melanoma group (p = 0.001). This pilot study shows an altered immunological response to stressors in melanoma patients.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
CD4 Lymphocyte Count -
CD8-Positive T-Lymphocytes -
Case-Control Studies -
Chemokine CCL5 - blood
Chemokines - blood
Female -
Humans -
Interleukin-10 - blood
Interleukin-6 - blood
Killer Cells, Natural -
Male -
Melanoma - blood
Melanoma - immunology
Melanoma - psychology
Melanoma - surgery
Middle Aged -
Pilot Projects -
Skin Neoplasms - blood
Skin Neoplasms - immunology
Skin Neoplasms - psychology
Skin Neoplasms - surgery
Stress, Psychological - blood
Stress, Psychological - etiology
Stress, Psychological - immunology

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