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McAlpine, JN; Greimel, E; Brotto, LA; Nout, RA; Shash, E; Avall-Lundqvist, E; Friedlander, ML; Joly, F; Gynecologic Cancer InterGroup (GCIG).
Quality of life research in endometrial cancer: what is needed to advance progress in this disease site? Methodological considerations from the Gynecologic Cancer InterGroup Symptom Benefit Working Group brainstorming session, Leiden 2012.
Int J Gynecol Cancer. 2014; 24(9):1686-1692 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Greimel Elfriede Renate
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Abstract:
Quality of life (QoL) in endometrial cancer (EC) is understudied. Incorporation of QoL questionnaires and patient-reported outcomes in clinical trials has been inconsistent, and the tools and interpretation of these measures are unfamiliar to most practitioners. In 2012, the Gynecologic Cancer InterGroup Symptom Benefit Working Group convened for a brainstorming collaborative session to address deficiencies and work toward improving the quality and quantity of QoL research in women with EC. Through literature review and international expert contributions, we compiled a comprehensive appraisal of current generic and disease site-specific QoL assessment tools, strengths and weaknesses of these measures, assessment of sexual health, statistical considerations, and an exploration of the unique array of histopathologic and clinical factors that may influence QoL outcomes in women with EC. This collaborative composition is the first publication specific to EC that addresses methodology in QoL research and the components necessary to achieve high quality QoL data in clinical trials. Future recommendations regarding (1) the incorporation of patient-reported outcomes in all clinical trials in EC, (2) definition of an a priori hypothesis, (3) utilization of validated tools and consideration of new tools corresponding to new therapies or specific symptoms, (4) publication within the same time frame as clinical outcome data, and (5) attempt to correct for disease site-specific potential confounders are presented. Improved understanding of methodology in QoL research and an increased undertaking of EC-specific QoL research in clinical trials are imperative if we are to improve outcomes in women with EC.
Find related publications in this database (using NLM MeSH Indexing)
Biomedical Research -
Clinical Trials as Topic - methods
Endometrial Neoplasms - psychology
Endometrial Neoplasms - therapy
Female -
Health Services Needs and Demand -
Humans -
Prognosis -
Quality of Life - psychology

Find related publications in this database (Keywords)
Quality of life
Clinical trials
Endometrial cancer
Patient-reported outcomes
Sexual health
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