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SHR Neuro Krebs Kardio Lipid

Trapp, M; Trapp, EM; Egger, JW; Domej, W; Schillaci, G; Avian, A; Rohrer, PM; Hörlesberger, N; Magometschnigg, D; Cervar-Zivkovic, M; Komericki, P; Velik, R; Baulmann, J.
Impact of mental and physical stress on blood pressure and pulse pressure under normobaric versus hypoxic conditions.
PLoS One. 2014; 9(5):e89005-e89005 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Avian Alexander
Baulmann Johannes
Cervar-Zivkovic Mila
Domej Wolfgang
Egger Josef Wilhelm
Hörlesberger Nina
Komericki Peter
Rohrer Peter Michael
Trapp Eva-Maria
Trapp Michael

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Number of Figures: 1
Hypobaric hypoxia, physical and psychosocial stress may influence key cardiovascular parameters including blood pressure (BP) and pulse pressure (PP). We investigated the effects of mild hypobaric hypoxia exposure on BP and PP reactivity to mental and physical stress and to passive elevation by cable car. 36 healthy volunteers participated in a defined test procedure consisting of a period of rest 1, mental stress task (KLT-R), period of rest 2, combined mental (KLT-R) and physical task (bicycle ergometry) and a last period of rest both at Graz, Austria (353 m asl) and at the top station Dachstein (2700 m asl). Beat-to-beat heart rate and BP were analysed both during the test procedures at Graz and at Dachstein and during passive 1000 m elevation by cable car (from 1702 m to 2700 m). A significant interaction of kind of stress (mental vs. combined mental and physical) and study location (Graz vs. Dachstein) was found in the systolic BP (p = .007) and PP (p = .002) changes indicating that during the combined mental and physical stress task sBP was significantly higher under hypoxic conditions whereas sBP and PP were similar during mental stress both under normobaric normoxia (Graz) and under hypobaric hypoxia (Dachstein). During the passive ascent in cable car less trivialization (psychological coping strategy) was associated with an increase in PP (p = .004). Our data show that combined mental and physical stress causes a significant higher raise in sBP and PP under hypoxic conditions whereas isolated mental stress did not affect sBP and PP under hypoxic conditions. PP-reaction to ascent in healthy subjects is not uniform. BP reactions to ascent that represents an accumulation of physical (mild hypobaric hypoxia) and psychological stressors depend on predetermined psychological traits (stress coping strategies). Thus divergent cardiovascular reactions can be explained by applying the multidimensional aspects of the biopsychosocial concept.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Blood Pressure - physiology
Cardiovascular Physiological Phenomena -
Cross-Over Studies -
Exercise Test - methods
Female -
Heart Rate - physiology
Humans -
Hypoxia - physiopathology
Logistic Models -
Male -
Multivariate Analysis -
Pulse -
Stress, Psychological - physiopathology
Surveys and Questionnaires -
Young Adult -

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