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Richtig, E; Komericki, P; Trapp, M; Ott, A; Bisail, B; Egger, JW; Zalaudek, I.
Ratio of marked and excised sentinel lymph nodes and scintigraphic appearance time in melanoma patients with negative sentinel lymph node.
Eur J Surg Oncol. 2010; 36(8):783-788
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Autor/innen der Med Uni Graz:
Egger Josef Wilhelm
Komericki Peter
Ott Arthur
Richtig Erika
Trapp Michael
Zalaudek Iris
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Abstract:
Metastases can occur in up to 15% of all melanoma patients with negative sentinel lymph node examination (SN -). We retrospectively investigated the number of preoperatively marked sentinel lymph nodes (SNs) with lymphoscintigraphy and effectively surgically removed SNs in SN--patients with cutaneous melanoma >or=0.5 mm. Ratio of these parameters was calculated and impact of this ratio as well as impact of scintigraphic appearance time (SAT) on disease progression was studied. Data on 122 SN--patients--70 women (58%), mean age 56.5 years--were analyzed. Mean follow-up time was 58 months. Mean tumour thickness of all patients was 2.3 mm. In 51 patients (42%) the number of SNs marked in lymphoscintigraphy was higher than excised in surgery, in 47 patients (38%) the same number as marked was excised and in 24 patients (20%) a lower number was marked than excised. Metastases occurred in 17 patients (14%) after a mean time of 24.8 months. Mean tumour thickness (5.4 mm) was significantly higher in these patients than in the other patients (p = 0.000). Ratio of marked and excised SNs had no influence on disease progression; the only parameter influencing outcome was tumour thickness (p = 0.000). Short SAT was significantly associated with higher tumour thickness (p = 0.004). Our study indicates that, in routine clinical practice, it suffices to harvest the first SN, as the ratio of marked and excised SNs has no impact on disease progression. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Disease Progression -
Female -
Humans -
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis - diagnostic imaging
Male -
Melanoma - diagnostic imaging
Melanoma - pathology
Melanoma - surgery
Middle Aged -
Radionuclide Imaging -
Retrospective Studies -
Sentinel Lymph Node Biopsy - methods
Skin Neoplasms - diagnostic imaging
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Young Adult -

Find related publications in this database (Keywords)
Negative sentinel lymph node biopsy
Melanoma
Metastasis
lymphoscintigraphy
Scintigraphic appearance time
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