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SHR Neuro Krebs Kardio Lipid

Homayoon, N; Pirpamer, L; Franthal, S; Katschnig-Winter, P; Kögl, M; Seiler, S; Wenzel, K; Hofer, E; Deutschmann, H; Fazekas, F; Langkammer, C; Ropele, S; Schmidt, R; Schwingenschuh, P.
Nigral iron deposition in common tremor disorders.
Mov Disord. 2019; 34(1):129-132 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Deutschmann Hannes
Fazekas Franz
Franthal Sebastian
Hofer Edith
Homayoon Nina
Katschnig-Winter Petra
Langkammer Christian
Pirpamer Lukas
Ropele Stefan
Schmidt Reinhold
Schwingenschuh Petra
Seiler Stephan
Wenzel Karoline
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Abstract:
We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties. Mean nigral R2* rates were measured in 40 patients with tremor-dominant Parkinson's disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls. Tremor-dominant PD patients had significantly higher nigral R2* values (34.1 ± 5.7) than those with tremor in dystonia (30.0 ± 3.9), essential tremor (30.6 ± 4.8), and controls (30.0 ± 2.8). An R2* threshold of 31.15 separated tremor-dominant PD from controls with a sensitivity and specificity of 67.5% and 72%. The sensitivity and specificity for discrimination between PD and non-PD tremor patients was 67.5% and 60%. Iron content in the substantia nigra is significantly higher in tremor-dominant PD than in tremor in dystonia, essential tremor, and controls. Because of the considerable overlap, nigral R2* cannot be suggested as a useful diagnostic tool. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Biomarkers - analysis
Female -
Humans -
Iron - metabolism
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Parkinson Disease - diagnosis
Parkinson Disease - metabolism
Substantia Nigra - metabolism
Substantia Nigra - physiopathology
Tremor - metabolism
Tremor - physiopathology

Find related publications in this database (Keywords)
brain iron accumulation
essential tremor
tremor-dominant Parkinson's disease
tremor in dystonia
R2 Star
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