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SHR Neuro Krebs Kardio Lipid

Jouvent, E; Sun, ZY; De Guio, F; Duchesnay, E; Duering, M; Ropele, S; Dichgans, M; Mangin, JF; Chabriat, H.
Shape of the Central Sulcus and Disability After Subcortical Stroke: A Motor Reserve Hypothesis.
Stroke. 2016; 47(4):1023-1029 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Ropele Stefan
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Abstract:
Both brain and cognitive reserves modulate the clinical impact of chronic brain diseases. Whether a motor reserve also modulates the relationships between stroke and disability is unknown. We aimed to determine whether the shape of the central sulcus, a marker of the development of underlying motor connections, is independently associated with disability in patients with a positive history of small subcortical ischemic stroke. Shapes of central sulci were reconstructed from high-resolution magnetic resonance imaging and ordered without supervision according to a validated algorithm in 166 patients with a positive history of small subcortical ischemic stroke caused by CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), a severe monogenic cerebral small vessel disease affecting young patients. Ordinal logistic regression modeling was used to test the relationships between modified Rankin scale, a disability scale strongly weighted toward motor disability, and sulcal shape. Modified Rankin scale was strongly associated with sulcal shape, independent of age, sex, and level of education (proportional odds ratio =1.19, 95% confidence interval =1.06-1.35; P=0.002). Results remained significant after further adjustment for brain atrophy, volume of lacunes, and volume of white matter hyperintensities of presumed vascular origin. The severity of disability in patients with a positive history of small subcortical ischemic stroke caused by a severe cerebral small vessel disease is related to the shape of the central sulcus, independently of the main determinants of disability. These results support the concept of a motor reserve that could modulate the clinical severity in patients with a positive history of small subcortical ischemic stroke. © 2016 American Heart Association, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Algorithms -
Atrophy - pathology
Atrophy - physiopathology
Brain Mapping -
CADASIL - pathology
CADASIL - physiopathology
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Female -
Humans -
Image Processing, Computer-Assisted -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Recovery of Function - physiology
Stroke - pathology
Stroke - physiopathology
White Matter - pathology
White Matter - physiopathology

Find related publications in this database (Keywords)
CADASIL
central sulcus
cerebral cortex
motor reserve
stroke
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