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Davies, G; Armstrong, N; Bis, JC; Bressler, J; Chouraki, V; Giddaluru, S; Hofer, E; Ibrahim-Verbaas, CA; Kirin, M; Lahti, J; van der Lee, SJ; Le Hellard, S; Liu, T; Marioni, RE; Oldmeadow, C; Postmus, I; Smith, AV; Smith, JA; Thalamuthu, A; Thomson, R; Vitart, V; Wang, J; Yu, L; Zgaga, L; Zhao, W; Boxall, R; Harris, SE; Hill, WD; Liewald, DC; Luciano, M; Adams, H; Ames, D; Amin, N; Amouyel, P; Assareh, AA; Au, R; Becker, JT; Beiser, A; Berr, C; Bertram, L; Boerwinkle, E; Buckley, BM; Campbell, H; Corley, J; De Jager, PL; Dufouil, C; Eriksson, JG; Espeseth, T; Faul, JD; Ford, I; Generation Scotland; Gottesman, RF; Griswold, ME; Gudnason, V; Harris, TB; Heiss, G; Hofman, A; Holliday, EG; Huffman, J; Kardia, SL; Kochan, N; Knopman, DS; Kwok, JB; Lambert, JC; Lee, T; Li, G; Li, SC; Loitfelder, M; Lopez, OL; Lundervold, AJ; Lundqvist, A; Mather, KA; Mirza, SS; Nyberg, L; Oostra, BA; Palotie, A; Papenberg, G; Pattie, A; Petrovic, K; Polasek, O; Psaty, BM; Redmond, P; Reppermund, S; Rotter, JI; Schmidt, H; Schuur, M; Schofield, PW; Scott, RJ; Steen, VM; Stott, DJ; van Swieten, JC; Taylor, KD; Trollor, J; Trompet, S; Uitterlinden, AG; Weinstein, G; Widen, E; Windham, BG; Jukema, JW; Wright, AF; Wright, MJ; Yang, Q; Amieva, H; Attia, JR; Bennett, DA; Brodaty, H; de Craen, AJ; Hayward, C; Ikram, MA; Lindenberger, U; Nilsson, LG; Porteous, DJ; Räikkönen, K; Reinvang, I; Rudan, I; Sachdev, PS; Schmidt, R; Schofield, PR; Srikanth, V; Starr, JM; Turner, ST; Weir, DR; Wilson, JF; van Duijn, C; Launer, L; Fitzpatrick, AL; Seshadri, S; Mosley, TH; Deary, IJ.
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).
Mol Psychiatry. 2015; 20(2):183-192 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Hofer Edith
Koini Marisa
Petrovic Katja Elisabeth
Schmidt Helena
Schmidt Reinhold
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Abstract:
General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adults. We conducted a meta-analysis of genome-wide association studies of 31 cohorts (N=53,949) in which the participants had undertaken multiple, diverse cognitive tests. A general cognitive function phenotype was tested for, and created in each cohort by principal component analysis. We report 13 genome-wide significant single-nucleotide polymorphism (SNP) associations in three genomic regions, 6q16.1, 14q12 and 19q13.32 (best SNP and closest gene, respectively: rs10457441, P=3.93 × 10(-9), MIR2113; rs17522122, P=2.55 × 10(-8), AKAP6; rs10119, P=5.67 × 10(-9), APOE/TOMM40). We report one gene-based significant association with the HMGN1 gene located on chromosome 21 (P=1 × 10(-6)). These genes have previously been associated with neuropsychiatric phenotypes. Meta-analysis results are consistent with a polygenic model of inheritance. To estimate SNP-based heritability, the genome-wide complex trait analysis procedure was applied to two large cohorts, the Atherosclerosis Risk in Communities Study (N=6617) and the Health and Retirement Study (N=5976). The proportion of phenotypic variation accounted for by all genotyped common SNPs was 29% (s.e.=5%) and 28% (s.e.=7%), respectively. Using polygenic prediction analysis, ~1.2% of the variance in general cognitive function was predicted in the Generation Scotland cohort (N=5487; P=1.5 × 10(-17)). In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Atherosclerosis - complications
Cognition - physiology
Cognition Disorders - etiology
Cognition Disorders - genetics
Cohort Studies -
Female -
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study -
HMGN1 Protein - genetics
Humans -
Male -
Middle Aged -
Neuropsychological Tests -
Phenotype -
Polymorphism, Single Nucleotide - genetics
Polymorphism, Single Nucleotide -

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