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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Kaps, M; Grittner, U; Jungehülsing, G; Tatlisumak, T; Kessler, C; Schmidt, R; Jukka, P; Norrving, B; Rolfs, A; Tanislav, C; sifap1 Investigators.
Clinical signs in young patients with stroke related to FAST: results of the sifap1 study.
BMJ Open. 2014; 4(11):e005276-e005276 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Schmidt Reinhold

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The present study aimed to evaluate the frequency of warning signs in younger patients with stroke with a special regard to the 'FAST' scheme, a public stroke recognition instrument (face, arm, speech, timely). Primary stroke care in participating centres of a multinational European prospective cross-sectional study (Stroke in Young Fabry Patients; sifap1). Forty-seven centres from 15 European countries participate in sifap1. 5023 acute patients with stroke (aged 18-55 years) patients (96.5% Caucasians) were enrolled in the study between April 2007 and January 2010. sifap1 was originally designed to investigate the relation of juvenile stroke and Fabry disease. A secondary aim of sifap1 was to investigate stroke patterns in this specific group of patients. The present investigation is a secondary analysis addressing stroke presenting symptoms with a special regard to signs included in the FAST scheme. 4535 patients with transient ischaemic attack (TIA; n=1071), ischaemic stroke (n=3396) or other (n=68) were considered in the presented analysis. FAST symptoms could be traced in 76.5% of all cases. 35% of those with at least one FAST symptom had all three symptoms. At least one FAST symptom could be recognised in 69.1% of 18-24 years-old patients, in 74% of those aged 25-34 years, in 75.4% of those aged 35-44 years, and 77.8% in 45-55 years-old patients. With increasing stroke severity signs included in the FAST scheme were more prevalent (National Institute of Health Stroke Scale, NIHSS<5: 69%, NIHSS 6-15: 98.9%, NIHSS>15: 100%). Clustering clinical signs according to FAST lower percentages of strokes in the posterior circulation (65.2%) and in patients with TIA (62.3%) were identified. FAST may be applied as a useful and rapid tool to identify stroke symptoms in young individuals aged 18-55 years. Especially in patients eligible for thrombolysis FAST might address the majority of individuals. The study was registered in (No. NCT00414583). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Cross-Sectional Studies -
Female -
Humans -
Male -
Middle Aged -
Prospective Studies -
Stroke - diagnosis
Symptom Assessment - methods
Young Adult -

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