Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Wenzel, K; Homann, CN; Fabbrini, G; Colosimo, C.
The role of subcutaneous infusion of apomorphine in Parkinson's disease.
Expert Rev Neurother. 2014; 14(7):833-843
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Homann Carl
Wenzel Karoline

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Plum Analytics:
Continuous subcutaneous apomorphine infusion therapy (CSAI) has proved to be effective in advanced Parkinson's Disease patients with motor fluctuations not controlled by oral or transdermal medication. In this clinical setting it competes directly with intrajejunal levodopa and deep brain stimulation (DBS), however randomised controlled comparative studies are lacking. The advantages of CSAI is that it is the least invasive of these three therapeutic options, is reversible, practical to use and has shown significant efficacy for the management of both peak-effect dyskinesias and off-period nonmotor-symptoms. Contraindications to the use of CSAI are severe dementia or neuropsychiatric symptoms and severe biphasic dyskinesias, however unlike DBS, advanced age is not a contraindication. This review summarises the evidence regarding efficacy, safety and tolerability of CSAI, provides guidance on the selection of suitable patients and gives practical instructions on how to initiate CSAI and manage possible adverse events.
Find related publications in this database (using NLM MeSH Indexing)
Antiparkinson Agents - administration & dosage
Antiparkinson Agents - history
Antiparkinson Agents - pharmacology
Apomorphine - administration & dosage
Apomorphine - history
Apomorphine - pharmacology
Deep Brain Stimulation -
History, 19th Century -
History, 20th Century -
Humans -
Infusions, Subcutaneous - methods
Parkinson Disease - history
Parkinson Disease - therapy

Find related publications in this database (Keywords)
levodopa-induced fluctuations
Parkinson's disease
subcutaneous infusion
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