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Koegl-Wallner, M; Katschnig-Winter, P; Pendl, T; Melisch, B; Trummer, M; Holl, E; Werner, U; Schmidt, R; Schwingenschuh, P.
Tremor associated with Klinefelter syndrome--a case series and review of the literature.
Parkinsonism Relat Disord. 2014; 20(3):323-327 (- Case Report)
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Autor/innen der Med Uni Graz:
Holl Etienne
Katschnig-Winter Petra
Melisch Barbara
Pendl Tamara
Schmidt Reinhold
Schwingenschuh Petra
Trummer Martin
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Abstract:
Previous case series suggested a link between Klinefelter syndrome (KS) and essential tremor (ET) or an ET-like syndrome. We investigated three KS-patients with tremor including tremor-analyzes and discuss our data in context to findings from a literature review. The clinical outcome after deep brain stimulation (DBS) is also reviewed. Tremor in KS is predominantly a postural and kinetic tremor that resembles ET. Our patients were further characterized by absent family history for tremor in first degree relatives, lack of subjective alcohol responsiveness inquired by history, and tremor onset in childhood. One of our patients and two cases from literature improved after DBS of the ventral intermediate nucleus (VIM) of the thalamus. Tremor in KS shares several features with ET. If other characteristics such as family history, alcohol responsiveness, and age at tremor onset may serve as discriminating factors from ET, needs to be further investigated. First observations suggest that VIM-DBS may be efficacious. Copyright © 2013 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Humans -
Klinefelter Syndrome - complications
Klinefelter Syndrome - diagnosis
Klinefelter Syndrome - genetics
Male -
Middle Aged -
Tremor - complications
Tremor - diagnosis
Tremor - genetics
Young Adult -

Find related publications in this database (Keywords)
Klinefelter syndrome
Essential tremor
Deep brain stimulation
DBS
Tremor analysis
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