Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Anderson, CD; Biffi, A; Nalls, MA; Devan, WJ; Schwab, K; Ayres, AM; Valant, V; Ross, OA; Rost, NS; Saxena, R; Viswanathan, A; Worrall, BB; Brott, TG; Goldstein, JN; Brown, D; Broderick, JP; Norrving, B; Greenberg, SM; Silliman, SL; Hansen, BM; Tirschwell, DL; Lindgren, A; Slowik, A; Schmidt, R; Selim, M; Roquer, J; Montaner, J; Singleton, AB; Kidwell, CS; Woo, D; Furie, KL; Meschia, JF; Rosand, J; on behalf of the International Stroke Genetics Consortium.
Common Variants Within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage.
Stroke. 2013; 44(3):612-619 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Schmidt Reinhold
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Abstract:
Background and Purpose-Previous studies demonstrated association between mitochondrial DNA variants and ischemic stroke (IS). We investigated whether variants within a larger set of oxidative phosphorylation (OXPHOS) genes encoded by both autosomal and mitochondrial DNA were associated with risk of IS and, based on our results, extended our investigation to intracerebral hemorrhage (ICH). Methods-This association study used a discovery cohort of 1643 individuals, a validation cohort of 2432 individuals for IS, and an extension cohort of 1476 individuals for ICH. Gene-set enrichment analysis was performed on all structural OXPHOS genes, as well as genes contributing to individual respiratory complexes. Gene-sets passing gene-set enrichment analysis were tested by constructing genetic scores using common variants residing within each gene. Associations between each variant and IS that emerged in the discovery cohort were examined in validation and extension cohorts. Results-IS was associated with genetic risk scores in OXPHOS as a whole (odds ratio [OR], 1.17; P=0.008) and complex I (OR, 1.06; P=0.050). Among IS subtypes, small vessel stroke showed association with OXPHOS (OR, 1.16; P=0.007), complex I (OR, 1.13; P=0.027), and complex IV (OR, 1.14; P=0.018). To further explore this small vessel association, we extended our analysis to ICH, revealing association between deep hemispheric ICH and complex IV (OR, 1.08; P=0.008). Conclusions-This pathway analysis demonstrates association between common genetic variants within OXPHOS genes and stroke. The associations for small vessel stroke and deep ICH suggest that genetic variation in OXPHOS influences small vessel pathobiology. Further studies are needed to identify culprit genetic variants and assess their functional consequences. (Stroke. 2013;44:612-619.)
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Case-Control Studies -
Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - genetics
Cohort Studies -
Female -
Genes - genetics
Genetic Predisposition to Disease - genetics
Genetic Variation - genetics
Genotype -
Humans -
Male -
Middle Aged -
Oxidative Phosphorylation -
Polymorphism, Single Nucleotide - genetics
Risk Factors -
Stroke - epidemiology Stroke - genetics

Find related publications in this database (Keywords)
genes
mitochondria
OXPHOS
stroke
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