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SHR Neuro Krebs Kardio Lipid

Strenger, V; Kessler, HH; Stelzl, E; Aberle, SW; Keldorfer, M; Zach, K; Karastaneva, A; Sperl, D; Lackner, H; Benesch, M; Urban, C; Dornbusch, HJ.
Enterovirus infections in pediatric hematologic/oncologic patients.
Pediatr Blood Cancer. 2019; 66(1):e27448-e27448
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Benesch Martin
Dornbusch Hans Jürgen
Karastaneva Anna
Keldorfer Markus
Kessler Harald
Lackner Herwig
Sperl Daniela
Stelzl Evelyn
Strenger Volker
Urban Ernst-Christian
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Abstract:
Enteroviruses (EV) are a large group of Picornaviruses associated with respiratory, gastrointestinal, and neurologic symptoms in the immunocompetent host. Little is known about the epidemiologic and clinical impact in pediatric hematologic/oncologic patients. From 2001 through 2017, different clinical specimens were collected from pediatric hematologic/oncologic patients and were tested for enteroviral RNA. Of 13 004 specimens collected from 761 patients, 38 (0.3%) obtained from 14 patients (1.8%) tested positive for EV RNA. Viral shedding was observed without viremia and vice versa. None of 80 cerebrospinal fluid specimens obtained from 60 patients with neurologic symptoms were positive for EV RNA. None of 14 patients positive for EV RNA showed EV-specific symptoms. In 11/14 patients, EV RNA was found to be negative in the follow-up specimen. The remaining patient with a severe primary immune deficiency showed repeated positive EV RNA results for >5 years. In this pediatric hematologic/oncologic cohort, EV infection occurred rarely and without related symptoms. Specimens concurrently obtained from one patient are commonly not in accordance with each other. In the vast majority of patients, EV RNA appears to turn negative in the follow-up specimen. EV infections seem to have a low impact in this patient cohort. © 2018 Wiley Periodicals, Inc.

Find related publications in this database (Keywords)
enterovirus
hematopoietic stem cell transplantation
immunodeficiency
pediatric hematologic/oncologic patients
picornavirus
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