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SHR Neuro Krebs Kardio Lipid

Hauer, AC.
Unconjugated hyperbilirubinemia. Laboratory and clinical differential diagnostics
MONATSSCHR KINDERH. 2017; 165(10): 907-921. [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Hauer Almuthe

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Unconjugated hyperbilirubinemia is characterised by an increased total serum bilirubin, with a direct bilirubin of < 15%. Jaundice of pre- or intrahepatic origin is the main clinical symptom. The most dangerous complication is bilirubin encephalopathy (kernicterus), particularly in neonates. Thus, it is essential to differentiate between the more frequent physiological and the much rarer pathological jaundice in order to initiate treatment in a timely manner. A stepwise screening guided by results is recommended: This includes systematic transcutaneous/invasive bilirubin measurements, assessment of measured values using age-related nomograms and differentiated diagnostics in a time-dependent correlation with the indirect hyperbilirubinemia's onset. Genetically determined disorders of bilirubin metabolism with varied degrees of severity (Gilbert disease; Crigler-Najjar syndrome I, II) also present initially with unconjugated hyperbilirubinemia.

Find related publications in this database (Keywords)
(Neonatal) jaundice
Meulengracht syndrome
Crigler-Najjar syndrome
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