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SHR Neuro Krebs Kardio Lipid

Kilday, JP; Caldarelli, M; Massimi, L; Chen, RH; Lee, YY; Liang, ML; Parkes, J; Naiker, T; van Veelen, ML; Michiels, E; Mallucci, C; Pettorini, B; Meijer, L; Dorfer, C; Czech, T; Diezi, M; Schouten-van Meeteren, AYN; Holm, S; Gustavsson, B; Benesch, M; Müller, HL; Hoffmann, A; Rutkowski, S; Flitsch, J; Escherich, G; Grotzer, M; Spoudeas, HA; Azquikina, K; Capra, M; Jiménez-Guerra, R; MacDonald, P; Johnston, DL; Dvir, R; Constantini, S; Kuo, MF; Yang, SH; Bartels, U.
Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN.
Neuro Oncol. 2017; 19(10):1398-1407 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Benesch Martin
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Abstract:
Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of intracystic therapy remains unclear. We report the retrospective experiences of several global centers using intracystic interferon-alpha. European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric Neurosurgery centers were contacted to submit a datasheet capturing pediatric patients with cystic craniopharyngiomas who had received intracystic interferon-alpha. Patient demographics, administration schedules, adverse events, and outcomes were obtained. Progression was clinical or radiological (cyst reaccumulation, novel cysts, or solid growth). Fifty-six children (median age, 6.3 y) from 21 international centers were identified. Median follow-up from diagnosis was 5.1 years (0.3-17.7 y). Lesions were cystic (n = 22; 39%) or cystic/solid (n = 34; 61%). Previous progression was treated in 43 (77%) patients before interferon use. In such cases, further progression was delayed by intracystic interferon compared with the preceding therapy for cystic lesions (P = 0.0005). Few significant attributable side effects were reported. Progression post interferon occurred in 42 patients (median 14 mo; 0-8 y), while the estimated median time to definitive therapy post interferon was 5.8 (1.8-9.7) years. Intracystic interferon-alpha can delay disease progression and potentially offer a protracted time to definitive surgery or radiotherapy in pediatric cystic craniopharyngioma, yet demonstrates a favorable toxicity profile compared with other therapeutic modalities-important factors for this developing age group. A prospective, randomized international clinical trial assessment is warranted. © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Child -
Child, Preschool -
Craniopharyngioma - metabolism
Craniopharyngioma - radiotherapy
Female -
Humans -
Injections, Intralesional - methods
Interferon-alpha - metabolism
Male -
Pituitary Neoplasms - radiotherapy
Retrospective Studies -

Find related publications in this database (Keywords)
craniopharyngioma
intracystic interferon
pediatric
retrospective
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