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SHR Neuro Krebs Kardio Lipid

Paar, M; Rossmann, C; Nusshold, C; Wagner, T; Schlagenhauf, A; Leschnik, B; Oettl, K; Koestenberger, M; Cvirn, G; Hallström, S.
Anticoagulant action of low, physiologic, and high albumin levels in whole blood.
PLoS One. 2017; 12(8):e0182997-e0182997 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Cvirn Gerhard
Hallström Seth
Köstenberger Martin
Leschnik Bettina
Nusshold Christoph
Öttl Karl
Paar Margret
Rossmann Christine Renate
Schlagenhauf Axel
Wagner Thomas
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Abstract:
Albumin is the most abundant plasma protein. Critical illness is often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. This study aimed to track the concentration-dependent influence of albumin on blood coagulation in vitro. Whole blood (WB) samples from 25 volunteers were prepared to contain low (19.3 ± 7.7 g/L), physiological (45.2 ± 7.8 g/L), and high (67.5 ± 18.1 g/L) levels of albumin. Haemostatic profiling was performed using a platelet function analyzer (PFA) 200, impedance aggregometry, a Cone and Platelet analyzer (CPA), calibrated automated thrombogram, and thrombelastometry (TEM). Platelet aggregation-associated ATP release was assessed via HPLC analysis. In the low albumin group, when compared to the physiological albumin group, we found: i) shortened PFA 200-derived closure times indicating increased primary haemostasis; ii) increased impedance aggregometry-derived amplitudes, slopes, ATP release, as well as CPA-derived average size indicating improved platelet aggregation; iii) increased TEM-derived maximum clot firmness and alpha angles indicating enhanced clot formation. TEM measurements indicated impaired clot formation in the high albumin group compared with the physiological albumin group. Thus, albumin exerted significant anticoagulant action. Therefore, low albumin levels, often present in cancer or critically ill patients, might contribute to the frequently occurring venous thromboembolism.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Anticoagulants - pharmacology
Blood Coagulation - drug effects
Blood Coagulation Tests -
Blood Platelets - cytology
Blood Platelets - drug effects
Blood Platelets - physiology
Cells, Cultured -
Female -
Humans -
Male -
Platelet Aggregation - drug effects
Platelet Function Tests -
Serum Albumin - pharmacology

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