Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Schalli, M; Weber, P; Tysoe, C; Pabst, BM; Thonhofer, M; Paschke, E; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG.
A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.
Bioorg Med Chem Lett. 2017; 27(15):3431-3435
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Pabst Bettina
Paschke Eduard
Tschernutter Marion
Windischhofer Werner
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
N-Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β-d-galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-galactosidase thus representing a new structural type of pharmacological chaperones for this lysosomal storage disease. Copyright © 2017 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Amination -
Animals -
Cattle -
Cyclopentanes - chemistry
Cyclopentanes - pharmacology
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Gangliosidosis, GM1 - drug therapy
Gangliosidosis, GM1 - enzymology
Humans -
Lysosomes - drug effects
Lysosomes - enzymology
Methylation -
beta-Galactosidase - antagonists & inhibitors
beta-Galactosidase - metabolism

Find related publications in this database (Keywords)
Aminocyclopentane
Carbafuranose
Galactosidase inhibitor
Pharmacological chaperone
G(M1)-Gangliosidosis
© Meduni Graz Impressum