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SHR Neuro Krebs Kardio Lipid

Odri Komazec, I; Posod, A; Schwienbacher, M; Resch, M; Pupp Peglow, U; Kiechl, S; Baumgartner, D; Kiechl-Kohlendorfer, U.
Aortic Elastic Properties in Preschool Children Born Preterm.
Arterioscler Thromb Vasc Biol. 2016; 36(11):2268-2274 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Baumgartner Daniela
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Abstract:
Preterm birth predisposes children to the development of cardiovascular diseases in adulthood. The aim of this study was to characterize elastic properties of the aorta at preschool age and test the hypothesis that prematurity is associated with decreased aortic distensibility and increased stiffness, both of which are predictors of increased cardiovascular risk. In an observational study of 76 five- to seven-year-old children born at a gestational age <32 weeks and 79 term-born controls, elastic parameters of the ascending and descending abdominal aorta were determined noninvasively by means of M mode echocardiographic tracings and calculated using computerized wall contour analysis. Compared with children born at term, the preterm group showed significantly reduced distensibility and increased stiffness of the descending abdominal aorta. These results remained significant under multivariable adjustment for birth weight z score, maternal smoking in pregnancy, maternal education, family history of cardiovascular disease, breastfeeding, childhood nutrition, and current body mass index z score (multivariable odds ratios and 95% confidence intervals 5.1, 1.7-15.9; P=0.005 and 2.8, 1.0-7.9; P=0.046, respectively). Further adjustment for intravenous lipid therapy attenuated the strength of association. Elastic properties of the ascending aorta did not differ between the 2 study groups. Children born preterm are characterized by decreased elastic properties of the descending abdominal aorta potentially attributable to impaired viscoelastic properties of and lipid damage to the aorta. Clinical follow-up of preterm infants with a focus on aortic elastic properties may be useful for tailoring early prevention programs and counteracting cardiovascular risk in adulthood. © 2016 American Heart Association, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Aorta, Abdominal - diagnostic imaging
Aorta, Abdominal - growth & development
Aorta, Abdominal - physiopathology
Aortic Diseases - diagnostic imaging
Aortic Diseases - etiology
Aortic Diseases - physiopathology
Aortography - methods
Case-Control Studies -
Chi-Square Distribution -
Child -
Child, Preschool -
Echocardiography -
Elasticity -
Female -
Gestational Age -
Humans -
Infant, Newborn -
Infant, Premature -
Male -
Multivariate Analysis -
Odds Ratio -
Pregnancy -
Premature Birth - physiopathology
Risk Factors -
Tomography, X-Ray Computed -
Vascular Stiffness -

Find related publications in this database (Keywords)
aorta
cardiovascular disease
elasticity
follow-up studies
pediatrics
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