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Cimenti, C; Schlagenhauf, A; Leschnik, B; Fröhlich-Reiterer, E; Jasser-Nitsche, H; Haidl, H; Suppan, E; Weinhandl, G; Leberl, M; Borkenstein, M; Muntean, WE.
Only minor changes in thrombin generation of children and adolescents with type 1 diabetes mellitus - A case-control study.
Thromb Res. 2016; 148(4):45-49
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Borkenstein Helmuth Martin
Cimenti Christina
Fröhlich-Reiterer Elke
Haidl Harald
Jasser-Nitsche Hildegard
Leschnik Bettina
Schlagenhauf Axel
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Abstract:
Micro- and macrovascular diseases are frequent complications in patients with diabetes. Hypercoagulability may contribute to microvascular alterations. In this study, we investigated whether type 1 diabetes in children is associated with a hypercoagulable state by performing a global function test of coagulation - the thrombin generation assay. 75 patients with type 1 diabetes aged between 2 and 19years were compared to an age-matched healthy control group. Diabetes patients were divided into high-dose and low-dose insulin cohorts with a cut-off at 0.8Ukg-1d-1. Measurements were performed with platelet poor plasma using Calibrated Automated Thrombography and 1 pM or 5 pM tissue factor. Additionally, we quantified prothrombin fragments F1+2, thrombin-antithrombin complex, prothrombin, tissue factor pathway inhibitor, and antithrombin. Patients with type 1 diabetes exhibited a significantly shorter of lag time as well as decreased thrombin peak and endogenous thrombin potential compared to control subjects with 5 pM but not with 1 pM tissue factor. In high-dose insulin patients peak thrombin generation was higher and time to peak shorter than in low-dose patients. Thrombin-antithrombin complex was decreased in patients with type 1 diabetes, whereas prothrombin fragments F1+2 was comparable in both groups. Thrombin generation parameters did not correlate with parameters of metabolic control and the duration of diabetes. Taken together, we found only minor changes of thrombin generation in children and adolescents with type 1 diabetes which - in contrast to type 2 diabetes - do not argue for a hypercoagulable state. Copyright © 2016 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Antithrombin III - metabolism
Blood Coagulation -
Case-Control Studies -
Child -
Child, Preschool -
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - metabolism
Female -
Humans -
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
Male -
Peptide Hydrolases - blood
Peptide Hydrolases - metabolism
Thrombin - analysis
Thrombin - metabolism
Young Adult -

Find related publications in this database (Keywords)
Hemostasis - blood coagulation test - diabetes mellitus
Type 1-child - adolescent
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