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SHR Neuro Krebs Kardio Lipid

Lechner, C; Baumann, M; Hennes, EM; Schanda, K; Marquard, K; Karenfort, M; Leiz, S; Pohl, D; Venkateswaran, S; Pritsch, M; Koch, J; Schimmel, M; Häusler, M; Klein, A; Blaschek, A; Thiels, C; Lücke, T; Gruber-Sedlmayr, U; Kornek, B; Hahn, A; Leypoldt, F; Sandrieser, T; Gallwitz, H; Stoffels, J; Korenke, C; Reindl, M; Rostásy, K.
Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease.
J Neurol Neurosurg Psychiatry. 2016; 87(8):897-905
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Gruber-Sedlmayr Ursula
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Abstract:
To determine the frequency and clinical-radiological associations of antibodies to myelin oligodendrocyte glycoprotein (MOG) and aquaporin-4 (AQP4) in children presenting with neuromyelitis optica (NMO) and limited forms. Children with a first event of NMO, recurrent (RON), bilateral ON (BON), longitudinally extensive transverse myelitis (LETM) or brainstem syndrome (BS) with a clinical follow-up of more than 12 months were enrolled. Serum samples were tested for MOG- and AQP4-antibodies using live cell-based assays. 45 children with NMO (n=12), LETM (n=14), BON (n=6), RON (n=12) and BS (n=1) were included. 25/45 (56%) children had MOG-antibodies at initial presentation (7 NMO, 4 BON, 8 ON, 6 LETM). 5/45 (11%) children showed AQP4-antibodies (3 NMO, 1 LETM, 1 BS) and 15/45 (33%) were seronegative for both antibodies (2 NMO, 2 BON, 4 RON, 7 LETM). No differences were found in the age at presentation, sex ratio, frequency of oligoclonal bands or median EDSS at last follow-up between the three groups. Children with MOG-antibodies more frequently (1) had a monophasic course (p=0.018) after one year, (2) presented with simultaneous ON and LETM (p=0.004) and (3) were less likely to receive immunosuppressive therapies (p=0.0002). MRI in MOG-antibody positive patients (4) less frequently demonstrated periependymal lesions (p=0.001), (5) more often were unspecific (p=0.004) and (6) resolved more frequently (p=0.016). 67% of all children presenting with NMO or limited forms tested positive for MOG- or AQP4-antibodies. MOG-antibody positivity was associated with distinct features. We therefore recommend to measure both antibodies in children with demyelinating syndromes. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Aquaporin 4 - blood
Aquaporin 4 - immunology
Autoantibodies - blood
Autoantibodies - immunology
Brain Stem - diagnostic imaging
Brain Stem - pathology
Child -
Child, Preschool -
Female -
Humans -
Infant -
Leukocytosis - cerebrospinal fluid
Magnetic Resonance Imaging -
Male -
Myelin-Oligodendrocyte Glycoprotein - blood
Myelin-Oligodendrocyte Glycoprotein - immunology
Myelitis, Transverse - blood
Myelitis, Transverse - cerebrospinal fluid
Myelitis, Transverse - diagnostic imaging
Myelitis, Transverse - immunology
Neuroimaging -
Neuromyelitis Optica - blood
Neuromyelitis Optica - cerebrospinal fluid
Neuromyelitis Optica - diagnostic imaging
Neuromyelitis Optica - immunology
Oligoclonal Bands - cerebrospinal fluid
Risk Factors -
Syndrome -

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