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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Thonhofer, M; Weber, P; Gonzalez Santana, A; Tysoe, C; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG.
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.
Carbohydr Res. 2016; 429(3):71-80
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Pabst Bettina
Paschke Eduard
Tschernutter Marion
Windischhofer Werner

Dimensions Citations:

Plum Analytics:
From an easily available partially protected analog of 1-deoxy-L-gulo-nojirimycin, by chain-branching at C-4 and suitable modification, lipophilic analogs of the powerful β-D-galactosidase inhibitor 4-epi-isofagomine have been prepared. New compounds exhibit considerably improved inhibitory activities when compared with the unsubstituted parent compound and may serve as leads toward new pharmacological chaperones for GM1-gangliosidosis and Morquio B disease. Copyright © 2016 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
1-Deoxynojirimycin - analogs & derivatives
1-Deoxynojirimycin - chemistry
Gangliosidosis, GM1 - drug therapy
Humans -
Hydrophobic and Hydrophilic Interactions -
Imino Pyranoses - chemical synthesis
Imino Pyranoses - chemistry
Mucopolysaccharidosis IV - drug therapy
beta-Galactosidase - antagonists & inhibitors
beta-Galactosidase - chemistry

Find related publications in this database (Keywords)
Galactosidase inhibitor
Pharmacological chaperone
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