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Biebl, A; Muendlein, A; Kinz, E; Drexel, H; Kabesch, M; Zenz, W; Elling, R; Müller, C; Keil, T; Lau, S; Simma, B.
Confirmation of Host Genetic Determinants in the CFH Region and Susceptibility to Meningococcal Disease in a Central European Study Sample.
Pediatr Infect Dis J. 2015; 34(10):1115-1117
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Autor/innen der Med Uni Graz:
Biebl Ariane
Zenz Werner
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Abstract:
Invasive meningococcal disease (IMD) is a leading cause of meningitis and severe sepsis in children and adolescents. Genetic factors are important in determining the susceptibility to and outcome of IMD. Recently, a genome-wide association study from the United Kingdom showed significant associations of single-nucleotide polymorphisms within complement factor H (CFH; rs1065489) and in CFH-related protein 3 (rs426736) with susceptibility of IMD. We report data of a genetic replication study in Central European children. The study was conducted as a retrospective case-reference study involving 248 patients with confirmed diagnosis of IMD from Austria and Germany and 835 healthy reference individuals from a multicenter German birth cohort. Carriers of the minor alleles of rs1065489 and rs426736 were at lower risk of IMD [allelic odds ratio = 0.60 (0.44-0.82); P = 0.001 and 0.61 (0.45-0.83); P = 0.001]. Also, 2 major haplotypes (GT and TC) derived from the 2 single-nucleotide polymorphisms were significantly associated with IMD (P = 0.001 and P = 0.003, respectively). The consistency of the results between the genome-wide association study and our study population strengthens the association of CFH polymorphisms to the susceptibility of IMD. Our results support the conclusion that CFH is a critical determinant in acquiring meningococcal disease.
Find related publications in this database (using NLM MeSH Indexing)
- epidemiology
Child -
Complement Factor H - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study -
Genotype -
Genotype - epidemiology
Humans -
Meningococcal Infections - epidemiology
Meningococcal Infections - genetics
Polymorphism, Single Nucleotide - genetics
Retrospective Studies -

Find related publications in this database (Keywords)
meningococcal disease
CFH
genetics
SNP
children
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