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SHR Neuro Krebs Kardio Lipid

Hector, A; Kirn, T; Ralhan, A; Graepler-Mainka, U; Berenbrinker, S; Riethmueller, J; Hogardt, M; Wagner, M; Pfleger, A; Autenrieth, I; Kappler, M; Griese, M; Eber, E; Martus, P; Hartl, D.
Microbial colonization and lung function in adolescents with cystic fibrosis.
J Cyst Fibros. 2016; 15(3):340-349 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Eber Ernst
Pfleger Andreas
Wagner Marlies
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Abstract:
With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preserved lung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa. Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. Collectively, this study identified potentially protective and harmful microbial colonization patterns in adolescent CF patients. Further studies in different patient cohorts are required to evaluate these microbial patterns and to assess their clinical relevance. Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Aspergillus fumigatus - isolation & purification
Austria - epidemiology
Cystic Fibrosis - epidemiology
Cystic Fibrosis - microbiology
Cystic Fibrosis - physiopathology
Female -
Germany - epidemiology
Humans -
Lung - microbiology
Lung - physiopathology
Male -
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Microbial Interactions -
Pseudomonas Infections - diagnosis
Pseudomonas Infections - epidemiology
Pseudomonas Infections - physiopathology
Pseudomonas aeruginosa - isolation & purification
Pulmonary Aspergillosis - diagnosis
Pulmonary Aspergillosis - epidemiology
Pulmonary Aspergillosis - physiopathology
Respiratory Function Tests - methods
Staphylococcal Infections - diagnosis
Staphylococcal Infections - epidemiology
Staphylococcal Infections - physiopathology
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Find related publications in this database (Keywords)
Cystic fibrosis
Infection
Bacteria
Fungi
Lung
Colonization
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