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SHR Neuro Krebs Kardio Lipid

Thonhofer, M; Weber, P; Santana, AG; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG.
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Bioorg Med Chem Lett. 2016; 26(5):1438-1442
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Pabst Bettina
Paschke Eduard
Tschernutter Marion
Windischhofer Werner
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Abstract:
From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further elaboration, lipophilic analogs of the powerful β-d-galactosidase inhibitor 4-epi-isofagomine have become available. New compounds exhibit improved inhibitory activities comparable to benchmark compound NOEV (N-octyl-epi-valienamine) and may serve as leads towards improved and more selective pharmacological chaperones for GM1-gangliosidosis. Copyright © 2016 Elsevier Ltd. All rights reserved.

Find related publications in this database (Keywords)
Iminoalditol
4-epi-Isofagomine
Galactosidase inhibitor
Pharmacological chaperone
G(M1)-gangliosidosis
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