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Masoud-Landgraf, L; Zarfel, G; Kaschnigg, T; Friedl, S; Feierl, G; Wagner-Eibel, U; Eber, E; Grisold, AJ; Kittinger, C.
Analysis and Characterization of Staphylococcus aureus Small Colony Variants Isolated From Cystic Fibrosis Patients in Austria.
Curr Microbiol. 2016; 72(5):606-611 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Eber Ernst
Feierl Gebhard
Friedl Simone
Grisold Andrea
Kittinger Clemens
Masoud-Landgraf Lilian
Wagner-Eibel Ute
Zarfel Gernot
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Abstract:
Cystic fibrosis (CF) is the most common hereditary lung disease in the Caucasian population, characterized by viscous bronchial secretion, consecutive defective mucociliary clearance, and unavoidable colonization with microorganisms. Besides Pseudomonas aeruginosa, Staphylococcus aureus is the most common bacterial species colonizing the CF respiratory tract. Under antibiotic pressure S. aureus is able to switch to small colony variants (SCV). These small colony variants can invade epithelial cells, overcome antibiotic therapy inside the cells and can be the starting point for extracellular recolonization. The aim of the present study was the isolation and characterization of S. aureus small colony variants from Austrian cystic fibrosis patients. Samples collected from 147 patients were screened for the presence of S. aureus wild-type and small colony variants. Antibiotic susceptibility testing and determination of the small colony variants causing auxotrophism were performed. Wild-type isolates were assigned to corresponding small colony variants with spa typing. In total, 17 different small colony variant isolates and 12 corresponding wild-type isolates were obtained. 13 isolates were determined thymidine auxotroph, 2 isolates were auxotroph for hemin, and none of the tested isolates was auxotroph for both, respectively. The presence of SCVs is directly related to a poor clinical outcome, therefore a monitoring of SCV prevalence is recommended. This study revealed rather low SCV ratios in CF patients compared to other countries.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Anti-Bacterial Agents - pharmacology
Austria -
Child -
Child, Preschool -
Cystic Fibrosis - microbiology
Female -
Humans -
Infant -
Male -
Microbial Sensitivity Tests -
Middle Aged -
Staphylococcal Infections - microbiology
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - growth & development
Staphylococcus aureus - isolation & purification
Young Adult -

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