Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid

Plomgaard, AM; Hagmann, C; Alderliesten, T; Austin, T; van Bel, F; Claris, O; Dempsey, E; Franz, A; Fumagalli, M; Gluud, C; Greisen, G; Hyttel-Sorensen, S; Lemmers, P; Pellicer, A; Pichler, G; Benders, M.
Brain injury in the international multicenter randomized SafeBoosC phase II feasibility trial: cranial ultrasound and magnetic resonance imaging assessments.
Pediatr Res. 2016; 79(3):466-472 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Pichler Gerhard
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Abstract:
Abnormal cerebral perfusion during the first days of life in preterm infants is associated with higher grades of intraventricular hemorrhages and lower developmental score. In SafeBoosC II, we obtained a significant reduction of cerebral hypoxia by monitoring cerebral oxygenation in combination with a treatment guideline. Here, we describe (i) difference in brain injury between groups, (ii) feasibility of serial cranial ultrasound (cUS) and magnetic resonance imaging (MRI), (iii) local and central cUS assessment. Hundred and sixty-six extremely preterm infants were included. cUS was scheduled for day 1, 4, 7, 14, and 35 and at term-equivalent age (TEA). cUS was assessed locally (unblinded) and centrally (blinded). MRI at TEA was assessed centrally (blinded). Brain injury classification: no, mild/moderate, or severe. Severe brain injury did not differ significantly between groups: cUS (experimental 10/80, control 18/77, P = 0.32) and MRI (5/46 vs. 3/38, P = 0.72). Kappa values for local and central readers were moderate-to-good for severe and poor-to-moderate for mild/moderate injuries. At TEA, cUS and MRI were assessed in 72 and 64%, respectively. There was no difference in severe brain injury between groups. Acquiring cUS and MRI according the standard operating procedures must be improved for future trials. Whether monitoring cerebral oxygenation during the first 72 h of life prevents brain injury should be evaluated in larger multicenter trials.
Find related publications in this database (using NLM MeSH Indexing)
Birth Weight -
Brain Injuries - diagnostic imaging
Brain Injuries - pathology
Cerebral Hemorrhage - diagnostic imaging
Cerebral Hemorrhage - pathology
Cerebrovascular Circulation -
Feasibility Studies -
Gestational Age -
Hemorrhage - physiopathology
Humans -
Hypoxia - physiopathology
Infant, Newborn -
Infant, Premature, Diseases - diagnostic imaging
Infant, Premature, Diseases - pathology
International Cooperation -
Magnetic Resonance Imaging -
Observer Variation -
Oxygen - chemistry
Perfusion -
Skull - diagnostic imaging
Skull - pathology
Ultrasonography -

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