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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Lang, JA; Pearson, JT; Binder-Heschl, C; Wallace, MJ; Siew, ML; Kitchen, MJ; te Pas, AB; Fouras, A; Lewis, RA; Polglase, GR; Shirai, M; Hooper, SB.
Increase in pulmonary blood flow at birth: role of oxygen and lung aeration.
J Physiol. 2016; 594(5):1389-1398 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Autor/innen der Med Uni Graz:
Binder-Heschl Corinna

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Number of Figures: 5
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Lung aeration stimulates the increase in pulmonary blood flow (PBF) at birth, but the spatial relationships between PBF and lung aeration and the role of increased oxygenation remain unclear. Using simultaneous phase-contrast X-ray imaging and angiography, we have investigated the separate roles of lung aeration and increased oxygenation in PBF changes at birth using near-term (30 days of gestation) rabbit kits (n = 18). Rabbits were imaged before ventilation, then the right lung was ventilated with 100% nitrogen (N2), air or 100% O2 (oxygen), before all kits were switched to ventilation in air, followed by ventilation of both lungs using air. Unilateral ventilation of the right lung with 100% N2 significantly increased heart rate (from 69.4 ± 4.9 to 93.0 ± 15.0 bpm), the diameters of both left and right pulmonary axial arteries, number of visible vessels in both left and right lungs, relative PBF index in both pulmonary arteries, and reduced bolus transit time for both left and right axial arteries (from 1.34 ± 0.39 and 1.81 ± 0.43 s to 0.52 ± 0.17 and 0.89 ± 0.21 s in the left and right axial arteries, respectively). Similar changes were observed with 100% oxygen, but increases in visible vessel number and vessel diameter of the axial arteries were greater in the ventilated right lung during unilateral ventilation. These findings confirm that PBF increase at birth is not spatially related to lung aeration and that the increase in PBF to unventilated regions is unrelated to oxygenation, although oxygen can potentiate this increase. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Animals, Newborn -
Female -
Heart Rate -
Lung - blood supply
Lung - physiology
Oxygen - metabolism
Pregnancy -
Pulmonary Artery - physiology
Pulmonary Circulation -
Pulmonary Gas Exchange -
Pulmonary Ventilation -
Rabbits -

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