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SHR Neuro Krebs Kardio Lipid

Treiber, G; Prietl, B; Fröhlich-Reiterer, E; Lechner, E; Ribitsch, A; Fritsch, M; Rami-Merhar, B; Steigleder-Schweiger, C; Graninger, W; Borkenstein, M; Pieber, TR.
Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus - A randomized clinical trial.
Clin Immunol. 2015; 161(2):217-224
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Borkenstein Helmuth Martin
Fröhlich-Reiterer Elke
Graninger Winfried
Pieber Thomas
Prietl Barbara
Ribitsch Anja
Treiber Gerlies
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Abstract:
It is unknown if cholecalciferol is able to modify defects in regulatory T cells (Tregs) in type 1 diabetes (T1D). In this randomized, double-blind, placebo controlled trial 30 young patients with new-onset T1D were assigned to cholecalciferol (70IU/kgbodyweight/day) or placebo for 12months. Tregs were determined by FACS-analysis and functional tests were assessed with ex vivo suppression co-cultures at months 0, 3, 6 and 12. Suppressive capacity of Tregs increased (p<0.001) with cholecalciferol from baseline (-1.59±25.6%) to 3 (30.5±39.4%), 6 (44.6±23.8%) and 12months (37.2±25.0%) and change of suppression capacity from baseline to 12months was significantly higher (p<0.05) with cholecalciferol (22.2±47.2%) than placebo (-16.6±21.1%). Serum calcium and parathormone stayed within normal range. This is the first study, which showed that cholecalciferol improved suppressor function of Tregs in patients with T1D and vitamin D could serve as one possible agent in the development of immunomodulatory combination therapies for T1D. Copyright © 2015 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
C-Peptide - blood
Child -
Cholecalciferol - administration & dosage
Cholecalciferol - blood
Cholecalciferol - therapeutic use
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - immunology
Dietary Supplements -
Double-Blind Method -
Fasting - blood
Female -
Humans -
Male -
Pilot Projects -
Prospective Studies -
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - immunology
Time Factors -
Treatment Outcome -
Vitamins - administration & dosage
Vitamins - therapeutic use

Find related publications in this database (Keywords)
Type 1 diabetes
Regulatory T cells
Suppressive capacity
Vitamin D
Cholecalciferol
Randomized controlled trial
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