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Deutschmann, A; Schlagenhauf, A; Leschnik, B; Hoffmann, KM; Hauer, A; Muntean, W.
Onset of Thrombin Generation Occurs More Rapidly in Pediatric Patients With Celiac Disease.
J Pediatr Gastroenterol Nutr. 2015; 61(2):230-233 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Deutschmann Andrea
Hauer Almuthe
Hoffmann Karl Martin
Leschnik Bettina
Muntean Eugen
Schlagenhauf Axel
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Abstract:
Celiac disease (CD) is a risk factor for venous thromboembolism (VTE) and stroke, but the mechanisms are unclear. Continuous measurement of thrombin generation in plasma is a feasible way to detect hypercoagulable changes. The aim of this pilot study was to investigate thrombin generation in pediatric patients with CD compared with pediatric controls. Plasma samples were collected from 19 pediatric patients with CD and 20 healthy controls. In each patient diagnosed as having CD, thrombin generation was determined twice by means of calibrated automated thrombography. The first measurement was undertaken when CD was diagnosed; the second measurement was undertaken after normalization of their IgA antitissue transglutaminase antibody (tTG-Ab) titers following a gluten-free diet. In the controls, measurement for TTG-Ab and thrombin generation was undertaken once during recruitment. Patients with CD at diagnosis showed a significantly shorter lag time compared with controls (P < 0.001) and a shorter time-to-peak compared with controls (P < 0.02). These differences were no longer detectable after normalization of TTG-Ab values. The overall amount of generated thrombin, represented by the endogenous thrombin potential (ETP), showed no significant difference between the study groups. Our results show that alterations in coagulation can be found in untreated CD that may help to explain the described increased risk of stroke or VTE. A shorter lag time in patients with untreated CD indicates a more rapid onset of thrombin generation as a sign of hypercoagulability. ETP, the best predictive parameter for thromboembolic disease, however, was not altered.
Find related publications in this database (using NLM MeSH Indexing)
Blood Coagulation -
Blood Coagulation Tests -
Celiac Disease - blood
Celiac Disease - diet therapy
Child -
Diet, Gluten-Free -
Female -
Humans -
Immunoglobulin A - blood
Male -
Risk Factors -
Stroke -
Thrombin - analysis
Transglutaminases - immunology
Venous Thromboembolism -

Find related publications in this database (Keywords)
celiac disease
stroke
thrombin generation
venous thromboembolism
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