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SHR Neuro Krebs Kardio Lipid

Jahnel, J; Zöhrer, E; Alisi, A; Ferrari, F; Ceccarelli, S; De Vito, R; Scharnagl, H; Stojakovic, T; Fauler, G; Trauner, M; Nobili, V.
Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease.
J Pediatr Gastroenterol Nutr. 2015; 61(1):85-90
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Autor/innen der Med Uni Graz:
Fauler Günter
Jahnel Jörg
Scharnagl Hubert
Stojakovic Tatjana
Trauner Michael
Zöhrer Evelyn
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Abstract:
Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease (NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic persons serum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis. Children with NAFLD were compared with controls and classified by stages of fibrosis (NAFLD-F0, n = 27; NAFLD-F≥1, n = 65) based on liver-biopsy findings. Fasted metabolic and cholestasis status was assessed by several blood tests. BA profiles were measured by tandem mass spectrometry and compared with healthy controls (n = 105). Compared with controls, all of the NAFLD patients were overweight and showed significantly elevated glucose, insulin, aspartate transaminase, and alanine transaminase levels. Total serum BAs were lower in nonfibrotic NAFLD children than in a control cohort (1.73 vs 3.6 μmol/L) because low glycine-conjugated BA levels were incompletely compensated by increases in taurine-conjugated or unconjugated BA. In patients with fibrotic NAFLD, BA levels were lower than in controls (2.45 vs 3.6 μmol/L) but higher than in nonfibrotic patients (2.45 vs 1.73 μmol/L), and the BA pattern resembled that of healthy controls. Fibroblast growth factor 19 levels were significantly lower in both NAFLD groups than in controls (P ≤ 0.001) and were positively correlated with ursodeoxycholic acid levels. Our data indicate that serum BA levels decrease in early NAFLD and increase during progression to fibrosis. Given that BA levels are increased in cirrhotic adults, we postulate a continuous rise as NAFLD advances. BA may have a value as a noninvasive biomarker in pediatric NAFLD progression.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Bile Acids and Salts - blood
Case-Control Studies -
Child -
Child, Preschool -
Disease Progression -
Female -
Humans -
Liver - pathology
Liver Cirrhosis - blood
Liver Cirrhosis - etiology
Male -
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - complications
Young Adult -

Find related publications in this database (Keywords)
bile acids
children
fibroblast growth factor 19
hyperinsulinemia
liver fibrosis
nonalcoholic fatty liver disease
steatosis
TGR5
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