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SHR Neuro Krebs Kardio Lipid

Warncke, K; Liptay, S; Fröhlich-Reiterer, E; Scheuing, N; Schebek, M; Wolf, J; Rohrer, TR; Meissner, T; Holl, RW.
Vascular risk factors in children, adolescents, and young adults with type 1 diabetes complicated by celiac disease: results from the DPV initiative.
Pediatr Diabetes. 2016; 17(3):191-198
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Autor/innen der Med Uni Graz:
Fröhlich-Reiterer Elke
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Abstract:
Celiac disease (CD) is a common comorbidity of type 1 diabetes (T1D). Long-term consequences of CD are not completely understood, and adhering to a gluten-free diet is a burden for many patients. We investigated the effect of CD on vascular risk factors in a large cohort of T1D patients aged <20 yr. Within the longitudinal Diabetes Patienten Verlaufsdokumentation (DPV)-diabetes registry, data were analyzed from 59,909 < 20-yr-old T1D patients treated at 392 centers in Germany and Austria. A total of 974 patients with biopsy-proven celiac disease (BPCD) were compared with 28,398 patients without CD with respect to blood pressure (BP), lipids, glycohemoglobin (HbA1c ), body mass index (BMI), and reported smoking behavior. Patients with T1D and BPCD showed significantly lower high-density lipoprotein (HDL) cholesterol levels [median (interquartile range): 53.0 (43.0-62.6) mg/dL] than patients without CD [55.0 (45.0-66.0) mg/dL; p < 0.01; p < 0.001 after adjustment for confounding variables]. Systolic BP was lower in patients with CD [105.5 (100.0-112.5) mmHg] than in patients without CD [110.0 (102.0-117.0) mmHg; p < 0.0001; p < 0.001 after adjustment]. There were no significant differences regarding smoking behavior, BMI, or HbA1c . In a subgroup of 335 patients with BPCD, HDL cholesterol was measured 1 yr after diagnosis of CD:HDL increased by 8% (p < 0.01). Young people with T1D and CD have lower HDL cholesterol values than patients without CD. As low HDL cholesterol is associated with vascular risk, our findings support screening for CD and monitoring of HDL cholesterol in young people with T1D. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Blood Glucose -
Blood Pressure -
Body Mass Index -
Celiac Disease - blood
Celiac Disease - complications
Celiac Disease - physiopathology
Child -
Child, Preschool -
Cohort Studies -
Diabetes Mellitus, Type 1 - complications
Diabetic Angiopathies - blood
Diabetic Angiopathies - etiology
Diabetic Angiopathies - physiopathology
Female -
Humans -
Lipids - blood
Male -
Registries -
Risk Factors -
Smoking - adverse effects

Find related publications in this database (Keywords)
blood pressure
celiac disease
lipids
type 1 diabetes
vascular risk
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