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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Boettcher, C; Dost, A; Wudy, SA; Flechtner-Mors, M; Borkenstein, M; Schiel, R; Weitzel, D; Bechtold-Dalla Pozza, S; Wolf, J; Holl, RW; German/Austrian Diabetes Prospective Documentation Initiative.
Accuracy of blood glucose meters for self-monitoring affects glucose control and hypoglycemia rate in children and adolescents with type 1 diabetes.
Diabetes Technol Ther. 2015; 17(4):275-282
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Borkenstein Helmuth Martin

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Plum Analytics:
This study investigated the accuracy of blood glucose meters for self-monitoring and its influence on glycated hemoglobin (HbA1c) levels and the frequency of hypoglycemic coma. Self-measured and simultaneously obtained laboratory blood glucose values from 9,163 patients with type 1 diabetes <18 years of age in the German/Austrian Diabetes Prospective Documentation Initiative registry were analyzed by investigating their compliance with the International Organization for Standardization (ISO) criteria (versions 2003 and 2013) and by error grid analyses. Regression models elucidated effects on glucose control and hypoglycemia rates. Depending on the respective subgroup (defined by sex, age, duration of diabetes, mode of insulin therapy), 78.7-94.7% of the self-monitoring of blood glucose (SMBG) values met the old and 79.7-88.6% met the new ISO criteria. In Clarke and Parkes error grid analyses, the percentages of SMBG values in Zone A ranged between 92.8% and 94.6% (Clarke) and between 92.2% and 95.0% (Parkes). The patient group with SMBG devices measuring "far too low" (compared with the laboratory-obtained glucose levels) presented with a higher HbA1c level than those measuring "far too high," "too high," "identical/almost identical," or "too low" (based on quintiles of deviation). Performing "far too high" was associated with the highest rate of hypoglycemic coma in comparison with the other deviation quintiles. This study showed that current SMBG devices fulfilled neither the previous nor the new ISO criteria. Large deviations of the SMBG values from the "true" glucose levels resulted in higher HbA1c levels and markedly increased rates of hypoglycemic events.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Austria -
Blood Glucose Self-Monitoring - instrumentation
Blood Glucose Self-Monitoring - standards
Child -
Child, Preschool -
Data Accuracy -
Databases, Factual -
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetic Coma - epidemiology
Female -
Germany -
Glycated Hemoglobin A - analysis
Humans -
Hypoglycemia - epidemiology
Infant -
Male -
Prospective Studies -
Reference Values -

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