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SHR Neuro Krebs Kardio Lipid

Pichler, G; Cheung, PY; Tze-Fun, L; Li, ES; Schmölzer, GM.
Is renal tissue oxygen desaturation during severe hypoxia underestimated? An observational study in term newborn piglets.
Nephrology (Carlton). 2015; 20(2):107-109
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Autor/innen der Med Uni Graz:
Pichler Gerhard
Schmoelzer Georg

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Plum Analytics:
The kidney is an organ highly susceptible to injury by regional tissue oxygen desaturation during hypoxic episodes. Transcutaneous monitoring of renal tissue oxygen saturation is therefore of increasing interest. The aim of the present study was to compare renal tissue oxygen saturation measured by near-infrared spectroscopy (NIRS) during acute hypoxia in neonates directly on the kidney and transcutaneously. We hypothesized that transcutaneous renal tissue oxygen saturation measurements would be influenced by superficial tissue. Five term newborn piglets were anesthetized, instrumented and exposed to normocapnic hypoxia at an inspired oxygen concentration of 0.14. Regional tissue oxygen saturation (rSO₂) was simultaneously measured for comparison with the sensor of NIRS (Invos 5100, Somanetics Corp., Troy, MI, USA) applied directly on the left kidney (renaldirect rSO₂) and on the skin of right flank above the right kidney (renalskin rSO₂). Cerebral regional tissue oxygenation (cerebralskin rSO₂), arterial oxygen saturation, heart rate (HR) and mean arterial pressure (MAP) were also monitored. NIRS parameters were analyzed in 5 s intervals during first 2 min of hypoxia. Hypoxia was achieved with an arterial oxygen desaturation from median (range) 95.3% (86.8-98.0) to 23.5% (13.0-41.0) after 2 min. HR and MAP did not change significantly during hypoxia. There were pronounced and lower renaldirect rSO₂ readings when compared with those of renalskin rSO₂ with significant differences from 25 to 55 s after initiation of hypoxia. Changes of cerebralskin rSO₂ and renalskin rSO₂ were similar. Transcutaneous monitoring of renal tissue oxygen saturation may underestimate acute oxygen desaturation of the kidney during hypoxia in neonates. © 2015 Asian Pacific Society of Nephrology.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Animals, Newborn -
Blood Gas Monitoring, Transcutaneous - methods
Disease Models, Animal -
Hemodynamics -
Hypoxia - blood
Hypoxia - diagnosis
Hypoxia - physiopathology
Kidney - blood supply
Kidney - metabolism
Oxygen - blood
Oxygen Consumption -
Predictive Value of Tests -
Regional Blood Flow -
Renal Circulation -
Reproducibility of Results -
Severity of Illness Index -
Skin - blood supply
Skin - metabolism
Spectroscopy, Near-Infrared -
Swine -
Time Factors -

Find related publications in this database (Keywords)
regional tissue oxygenation
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