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Hoenigl, M; Zollner-Schwetz, I; Sill, H; Linkesch, W; Lass-Flörl, C; Schnedl, WJ; Krause, R.
Epidemiology of invasive fungal infections and rationale for antifungal therapy in patients with haematological malignancies.
Mycoses. 2011; 54(5):454-459
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Autor/innen der Med Uni Graz:
Hönigl Martin
Krause Robert
Linkesch Werner
Schnedl Wolfgang
Sill Heinz
Zollner-Schwetz Ines
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Abstract:
Invasive fungal infections (IFIs) in patients with haematological malignancies are difficult to diagnose and outcome is often fatal. Over the 7-month study period, 117 cases with haematological malignancies receiving systemic antifungal treatment were included. Data regarding antifungal agents, dosage and reason for administration were recorded. Fungal infections in study patients were classified as possible, probable or proven according to recent European Organization for Research and Treatment of Cancer criteria. During the study period, 690 cases with haematological malignancies were admitted. A total of 117 cases received systemic antifungal therapy. Twenty-four of 117 patients (21%) had possible, six (5.1%) had probable and four (3.4%) had proven IFI. Seven of 10 probable and proven infections were caused by Candida spp., 2 by Aspergillus spp. and 1 by a fungus belonging to Zygomycetes. Fifty-two of 117 patients (44%) received antifungal prophylaxis, 81 of 117 (69%) received empirical (31/117; 26%) or pre-emptive (50/117; 43%) antifungal therapy and four of 117 patients (3.4%) directed antifungal therapy. Mostly, systemic antifungal therapy was administered empirically or pre-emptively. Twenty-nine per cent of cases receiving systemic antifungal treatment met the international consensus criteria of mostly possible IFI, whereas 71% did not. Proven invasive fungal infections were rare. © 2010 Blackwell Verlag GmbH.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Antifungal Agents - therapeutic use
Chemoprevention - methods
Female -
Fungi - classification
Fungi - isolation & purification
Hematologic Neoplasms - complications
Humans -
Male -
Middle Aged -
Mycoses - drug therapy
Mycoses - epidemiology
Prospective Studies -

Find related publications in this database (Keywords)
Invasive fungal infection
antifungal agents
aspergillosis
candidiasis
haematological malignancies
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