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Zebisch, A; Hatzl, S; Pichler, M; Wölfler, A; Sill, H.
Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAs.
Int J Mol Sci. 2016; 17(12): [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Hatzl Stefan
Pichler Martin
Sill Heinz
Wölfler Albert
Zebisch Armin
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Abstract:
Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem or progenitor cells and displays the most frequent acute leukemia in adults. Although some patients can be cured with high dose chemotherapy and allogeneic hematopoietic stem cell transplantation, the majority still succumbs to chemoresistant disease. Micro-RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are non-coding RNA fragments and act as key players in the regulation of both physiologic and pathologic gene expression profiles. Aberrant expression of various non-coding RNAs proved to be of seminal importance in the pathogenesis of AML, as well in the development of resistance to chemotherapy. In this review, we discuss the role of miRNAs and lncRNAs with respect to sensitivity and resistance to treatment regimens currently used in AML and provide an outlook on potential therapeutic targets emerging thereof.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Drug Resistance, Neoplasm - genetics
Humans -
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Biological -
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism

Find related publications in this database (Keywords)
acute myeloid leukemia
risk stratification
chemoresistance
micro-RNA
long non-coding RNA
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