Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Juric, MK; Ghimire, S; Ogonek, J; Weissinger, EM; Holler, E; van Rood, JJ; Oudshoorn, M; Dickinson, A; Greinix, HT.
Milestones of Hematopoietic Stem Cell Transplantation - From First Human Studies to Current Developments
FRONT IMMUNOL. 2016; 7: UNSP 470 [OPEN ACCESS]
Web of Science FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Greinix Hildegard
Altmetrics:

Dimensions Citations:
Plum Analytics:

Abstract:
Since the early beginnings, in the 1950s, hematopoietic stem cell transplantation (HSCT) has become an established curative treatment for an increasing number of patients with life-threatening hematological, oncological, hereditary, and immunological diseases. This has become possible due to worldwide efforts of preclinical and clinical research focusing on issues of transplant immunology, reduction of transplant-associated morbidity, and mortality and efficient malignant disease eradication. The latter has been accomplished by potent graft-versus-leukemia (GvL) effector cells contained in the stem cell graft. Exciting insights into the genetics of the human leukocyte antigen (HLA) system allowed improved donor selection, including HLA-identical related and unrelated donors. Besides bone marrow, other stem cell sources like granulocyte-colony stimulating-mobilized peripheral blood stem cells and cord blood stem cells have been established in clinical routine. Use of reduced-intensity or non-myeloablative conditioning regimens has been associated with a marked reduction of non-hematological toxicities and eventually, non-relapse mortality allowing older patients and individuals with comorbidities to undergo allogeneic HSCT and to benefit from GvL or antitumor effects. Whereas in the early years, malignant disease eradication by high-dose chemotherapy or radiotherapy was the ultimate goal; nowadays, allogeneic HSCT has been recognized as cellular immunotherapy relying prominently on immune mechanisms and to a lesser extent on non-specific direct cellular toxicity. This chapter will summarize the key milestones of HSCT and introduce current developments.

Find related publications in this database (Keywords)
hematopoietic stem cell transplantation
milestones
conditioning
HLA typing
stem cell source
© Meduni Graz Impressum