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SHR Neuro Krebs Kardio Lipid

Rabitsch, W; Bojic, M; Wohlfarth, P; Leiner, M; Schörgenhofer, C; Kalhs, P; Schulenburg, A; Sillaber, C; Mitterbauer, M; Sperr, WR; Jäger, U; Skrabs, K; Greinix, H; Hermann, A; Lamm, W.
Alemtuzumab-BEAM as conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory Hodgkin lymphoma: a single-center analysis.
J Cancer Res Clin Oncol. 2016; 142(6):1307-1314 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Greinix Hildegard
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Number of Figures: 2
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Abstract:
Treatment of refractory Hodgkin disease deserves specific considerations. Recently, alemtuzumab-BEAM has been introduced in allogeneic hematopoietic stem cell transplantation (HSCT) in these patients. We retrospectively analyzed the outcome of 20 patients with relapsed/refractory Hodgkin's lymphoma (HL) who received allogeneic HSCT following conditioning therapy with alemtuzumab-BEAM. Treatment-related toxicity was tolerable. Half of the patients (50 %) had infections. Of these, 50 % were found to have pneumonia or catheter-related infections. In 20 %, an oral mucositis was observed. Acute graft-versus-host disease (GvHD) (≥grade 2) was seen in three patients. Complete remission (CR) could be achieved in 17 patients (85 %), 2 patients had persistent Hodgkin disease, and 1 patient died from infection prior to CR evaluation. Median progression-free survival and overall survival were 17.9 and 67.5 months, respectively. From the 17 CR patients, 8 had a relapse after a median of 10 months. Notably, of the eight patients relapsing after HSCT, all patients received another salvage treatment and four patients are still alive, whereas the other four patients died due to further progress. Six out of the remaining nine patients are still in CR, whereas the other three died from chronic GvHD and multi-organ failure. Overall, seven patients experienced chronic GvHD. In summary, alemtuzumab-BEAM is a well-tolerated conditioning therapy for allogeneic HSCT with high response rates in refractory HL.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Alemtuzumab -
Antibodies, Monoclonal, Humanized - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Carmustine - administration & dosage
Cytarabine - administration & dosage
Etoposide - administration & dosage
Female -
Graft vs Host Disease -
Hodgkin Disease - drug therapy
Hodgkin Disease - therapy
Humans -
Male -
Melphalan - administration & dosage
Recurrence -
Transplantation Conditioning -
Young Adult -

Find related publications in this database (Keywords)
Hodgkin lymphoma
Allogeneic HSCT
Alemtuzumab-BEAM
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