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SHR Neuro Krebs Kardio Lipid

Prattes, J; Duettmann, W; Hoenigl, M.
Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels.
Antimicrob Agents Chemother. 2016; 60(9):5595-5599 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Düttmann Wiebke
Hönigl Martin
Prattes Jürgen
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Abstract:
Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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Administration, Oral -
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