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SHR Neuro Krebs Kardio Lipid

Kinzer, M; Hingerl, K; König, J; Reinisch, A; Strunk, D; Huppertz, B; Lang, I.
Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.
Placenta. 2014; 35(7):517-519
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Autor/innen der Med Uni Graz:
Hingerl Kerstin
Huppertz Berthold
König Julia Maria
Lang-Olip Ingrid
Reinisch Andreas
Strunk Dirk
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Abstract:
Cell transplantation is a promising strategy in regenerative medicine for revascularization of ischemic tissues. Based on our observation that placental mesenchymal stromal cells (PMSC) enhance endothelial cell viability in vitro via secretion of angiogenic factors, we asked whether PMSC support vascular growth in vivo. PMSC were isolated from amnion and placental endothelial cells (PLEC) from chorion and either separately or co-transplanted subcutaneously into immune-deficient mice. Co-transplantation resulted in a higher number of perfused human vessels (CD31+/vimentin+) containing mouse glycophorin A+ erythrocytes. Results indicate positive effects of PMSC on neovascularization in vivo, making them attractive candidates to create autologous PMSC/PLEC pairs for research and transplantation. Copyright © 2014 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Endothelial Cells - physiology
Endothelial Cells - transplantation
Female -
Heterografts -
Humans -
Mesenchymal Stem Cell Transplantation -
Mesenchymal Stromal Cells - physiology
Mice -
Mice, Inbred NOD -
Mice, SCID -
Models, Animal -
Neovascularization, Physiologic -
Placenta - blood supply
Placenta - cytology
Pregnancy -
Regenerative Medicine -

Find related publications in this database (Keywords)
Human placenta
Mesenchymal stromal cells
Vascularization
Angiogenesis
Mouse model
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